ENSMUSG00000036698


Mus musculus

Features
Gene ID: ENSMUSG00000036698
  
Biological name :Ago2
  
Synonyms : Ago2 / Protein argonaute-2 / Q8CJG0
  
Possible biological names infered from orthology : argonaute 2, RISC catalytic component / Q9UKV8
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 73095844
Gene end: 73184935
  
Corresponding Affymetrix probe sets: 10429327 (MoGene1.0st)   10429329 (MoGene1.0st)   1426366_at (Mouse Genome 430 2.0 Array)   1435636_at (Mouse Genome 430 2.0 Array)   1455294_at (Mouse Genome 430 2.0 Array)   1455389_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042207
NCBI entrez gene - 239528     See in Manteia.
MGI - MGI:2446632
RefSeq - NM_153178
RefSeq Peptide - NP_694818
swissprot - Q8CJG0
Ensembl - ENSMUSG00000036698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago2ENSDARG00000061268Danio rerio
 AGO2ENSGALG00000040957Gallus gallus
 AGO2ENSG00000123908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*ENSMUSG0000004153082
Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*ENSMUSG0000002884279
Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSMUSG0000004250078
Piwil2 / Q8CDG1 / Piwi-like protein 2 / Q8TC59* / piwi like RNA-mediated gene silencing 2*ENSMUSG0000003364421
Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*ENSMUSG0000002942321
Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*ENSMUSG0000003691218


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028602  Protein argonaute-2
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0010586 miRNA metabolic process IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0031054 pre-miRNA processing IDA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035279 mRNA cleavage involved in gene silencing by miRNA IDA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045947 negative regulation of translational initiation IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0090625 mRNA cleavage involved in gene silencing by siRNA IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
 biological_processGO:1901165 positive regulation of trophoblast cell migration IEA
 biological_processGO:1905618 positive regulation of miRNA mediated inhibition of translation IEA
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 cellular_componentGO:0016442 RISC complex IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0070578 RISC-loading complex IDA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA ISO
 molecular_functionGO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA IEA
 molecular_functionGO:0098808 mRNA cap binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0001711 abnormal placenta 
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011171 increased number of Heinz bodies "presence of intracellular inclusions usually attached to the red blood cell membrane, resulting from oxidative injury to and precipitation of hemoglobin in red blood cells" [http://www.dorlands.com/]
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Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002227 Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSMUSG00000002731 Prkra / Q9WTX2 / Interferon-inducible double-stranded RNA-dependent protein kinase activator A / O75569* / protein activator of interferon induced protein kinase EIF2AK2*  / complex
 ENSMUSG00000023051 P97473 / Tarbp2 / TARBP2, RISC loading complex RNA binding subunit / Q15633*  / complex
 ENSMUSG00000025571 Tnrc6c / trinucleotide repeat containing 6C / Q9HCJ0*  / reaction / complex
 ENSMUSG00000026374 Tsn / Q62348 / translin / Q15631*  / reaction
 ENSMUSG00000047888 Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b / Q9UPQ9*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000041415 Dicer1 / dicer 1, ribonuclease III / Q9UPY3*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000028287 1700009N14Rik / RIKEN cDNA 1700009N14 gene / RAN* / P62826* / RAN, member RAS oncogene family*  / reaction
 ENSMUSG00000040029 Ipo8 / Q7TMY7 / Importin-8 / O15397*  / reaction / complex
 ENSMUSG00000056820 Tsnax / Q9QZE7 / Translin-associated protein X / Q99598* / TSNAX-DISC1* / translin associated factor X* / TSNAX-DISC1 readthrough (NMD candidate)*  / reaction






 

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