ENSMUSG00000041415


Mus musculus

Features
Gene ID: ENSMUSG00000041415
  
Biological name :Dicer1
  
Synonyms : Dicer1 / dicer 1, ribonuclease III
  
Possible biological names infered from orthology : Q9UPY3
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 104687742
Gene end: 104751952
  
Corresponding Affymetrix probe sets: 10402444 (MoGene1.0st)   1427941_at (Mouse Genome 430 2.0 Array)   1460571_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043676
Ensembl peptide - ENSMUSP00000152413
NCBI entrez gene - 192119     See in Manteia.
MGI - MGI:2177178
RefSeq - XM_017314999
RefSeq - XM_006515611
RefSeq - XM_017314997
RefSeq - XM_017314998
RefSeq - NM_148948
RefSeq - XM_006515608
RefSeq - XM_006515609
RefSeq Peptide - NP_683750
swissprot - F8VQ54
swissprot - A0A1Y7VJD6
Ensembl - ENSMUSG00000041415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dicer1ENSDARG00000001129Danio rerio
 DICER1ENSGALG00000010999Gallus gallus
 DICER1ENSG00000100697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fancm / Q8BGE5 / Fanconi anemia group M protein homolog / Q8IYD8* / Fanconi anemia complementation group M*ENSMUSG0000005588412
Ifih1 / Q8R5F7 / Interferon-induced helicase C domain-containing protein 1 / Q9BYX4* / interferon induced with helicase C domain 1*ENSMUSG000000268969
Dhx58 / Q99J87 / Probable ATP-dependent RNA helicase DHX58 / Q96C10* / DExH-box helicase 58*ENSMUSG000000178308
Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*ENSMUSG000000402968


Protein motifs (from Interpro)
Interpro ID Name
 IPR000999  Ribonuclease III domain
 IPR001650  Helicase, C-terminal
 IPR003100  PAZ domain
 IPR005034  Dicer dimerisation domain
 IPR006935  Helicase/UvrB, N-terminal
 IPR011907  Ribonuclease III
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014720  Double-stranded RNA-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036085  PAZ domain superfamily
 IPR036389  Ribonuclease III, endonuclease domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0016075 rRNA catabolic process IEA
 biological_processGO:0030422 production of siRNA involved in RNA interference IEA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0033168 conversion of ds siRNA to ss siRNA involved in RNA interference IEA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0036404 conversion of ds siRNA to ss siRNA IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0004525 ribonuclease III activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016891 endoribonuclease activity, producing 5"-phosphomonoesters IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0070883 pre-miRNA binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kitd18/Kit+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1.1Snj/Dicer1tm1.1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mybboo/Mybboo
Genetic Background: involves: C57BL/6

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Kitd18/Kit+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbs-15DttMb/Ednrbs
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0001280 loss of vibrissae "inability to retain the whiskers" [J:45400]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asxl1tm1.1Mjxu/Asxl1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kitd18/Kit+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dicer1tm1.1Vlcg/Dicer1tm2.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dicer1tm1.1Snj/Dicer1tm1.1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Kitd18/Kit+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dicer1tm1.1Bdh/Dicer1tm1.1Bdh
Genetic Background: involves: 129

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tmc1baringo/Tmc1baringo
Genetic Background: involves: C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1.1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA * FVB/N

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ednrbs-15DttMb/Ednrbs
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

Allelic Composition: Dicer1em1Psv/Dicer1em1Psv
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dicer1em2Psv/Dicer1em2Psv
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53+,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1.1Snj/Dicer1tm1.1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dicer1tm2.1Vlcg/Dicer1tm2.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Dicer1tm1.1Doca/Dicer1tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tmc1baringo/Tmc1baringo
Genetic Background: involves: C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0002827 abnormal renal corpuscle "anomalous structure or development of either Bowman s capsules and/or the glomeruli contained therein" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003574 abnormal oviduct morphology "malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0003579 ovarian carcinoma 
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0003670 dilated glomerular capsule "an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003700 abnormal oviduct transport "increased or decreased rate of passage of embryos or oocytes from the ovary to the uterus" [J:97633, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003875 abnormal hair follicle regresssion "abnormal length of time for the onset of catagen phase of the cyclic trasnformation of the hair follicle " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0004208 basal cell carcinoma "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53+,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0004728 abnormal efferent ductules of testis "any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0004880 lung cysts 
Show

Allelic Composition: Clk2tm1.1Ppgr/Clk2tm1.1Ppgr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6NTac * FVB/N

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0004941 abnormal regulatory T cell morphology "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1.1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(IghelMD4)4Ccg/0,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(BCL2)22Wehi/0
Genetic Background: involves: BALB/c * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbs-15DttMb/Ednrbs
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Dicer1em1Psv/Dicer1em1Psv
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dicer1em2Psv/Dicer1em2Psv
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0006428 ectopic Sertoli cells "abnormal position of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008018 facial tumor "presence of abnormal, rapidly proliferating cells on the face usually in the form of a distinct mass " [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0008094 absent memory B cells "absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmc1baringo/Tmc1baringo
Genetic Background: involves: C57BL/6

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmc1baringo/Tmc1baringo
Genetic Background: involves: C57BL/6

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Tmc1baringo/Tmc1baringo
Genetic Background: involves: C57BL/6

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Tmc1baringo/Tmc1baringo
Genetic Background: involves: C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(IghelMD4)4Ccg/0,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(BCL2)22Wehi/0
Genetic Background: involves: BALB/c * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0008257 thin myometrium "reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008755 abnormal immunoglobulin V(D)J recombination "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1.1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Sap130b2b635.2Clo/Sap130b2b635.2Clo
Genetic Background: C57BL/6J-Sap130b2b635.2Clo

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0009071 short oviduct "length reduction or truncation of the tube through which the ova pass from the ovary to the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0009089 short uterine horn "length reduction or truncation of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0009096 decreased endometrial gland number "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0009140 dilated efferent ductules of testis "an expansion in the volume or area of the lumen of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0009439 myeloid sarcoma "malignant tumor of immature myeloid cells, often associaed with or preceeding granulocytic leukemia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0009544 abnormal thymus epithelium morphology "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd

 MP:0009600 hypergranulosis "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Ednrbs-15DttMb/Ednrbs
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Dicer1em1Psv/Dicer1em1Psv
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dicer1em2Psv/Dicer1em2Psv
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0010241 abnormal aortic arch development "anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Trp53tm1Brn/Trp53+,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0010964 increased compact bone volume 
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1.1Vlcg/Dicer1tm2.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dicer1tm1.1Bdh/Dicer1tm1.1Bdh
Genetic Background: involves: 129

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011147 increased mesenchymal cell proliferation involved in lung development "increase in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011846 decreased kidney collecting duct number "smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [MGI:anna]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0013305 isosthenuria "inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake" [MGI:Anna]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0014194 increased epididymal epithelium cell proliferation "increase in the expansion rate of the cells of the epididymal epithelium by cell division" [MGI:Anna]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0030025 giant platelets "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx]
Show

Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023051 P97473 / Tarbp2 / TARBP2, RISC loading complex RNA binding subunit / Q15633*  / complex
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / complex
 ENSMUSG00000002731 Prkra / Q9WTX2 / Interferon-inducible double-stranded RNA-dependent protein kinase activator A / O75569* / protein activator of interferon induced protein kinase EIF2AK2*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr