ENSMUSG00000023051


Mus musculus

Features
Gene ID: ENSMUSG00000023051
  
Biological name :Tarbp2
  
Synonyms : P97473 / Tarbp2 / TARBP2, RISC loading complex RNA binding subunit
  
Possible biological names infered from orthology : Q15633
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102518192
Gene end: 102523676
  
Corresponding Affymetrix probe sets: 10427255 (MoGene1.0st)   1423616_at (Mouse Genome 430 2.0 Array)   1438952_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120315
Ensembl peptide - ENSMUSP00000155826
Ensembl peptide - ENSMUSP00000154902
Ensembl peptide - ENSMUSP00000123339
Ensembl peptide - ENSMUSP00000123213
Ensembl peptide - ENSMUSP00000121748
Ensembl peptide - ENSMUSP00000023813
Ensembl peptide - ENSMUSP00000097744
Ensembl peptide - ENSMUSP00000117964
NCBI entrez gene - 21357     See in Manteia.
MGI - MGI:103027
RefSeq - XM_006520719
RefSeq - XM_006520723
RefSeq - XM_006520722
RefSeq - XM_006520721
RefSeq - NM_001253795
RefSeq - NM_009319
RefSeq - XM_006520720
RefSeq - XM_006520724
RefSeq Peptide - NP_033345
RefSeq Peptide - NP_001240724
swissprot - Q3UNH9
swissprot - P97473
swissprot - D6RE49
swissprot - D3YZS5
swissprot - D3Z033
swissprot - D3Z282
swissprot - D6RCY4
Ensembl - ENSMUSG00000023051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tarbp2ENSDARG00000070471Danio rerio
 TARBP2ENSGALG00000038939Gallus gallus
 Q15633ENSG00000139546Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkra / Q9WTX2 / Interferon-inducible double-stranded RNA-dependent protein kinase activator A / O75569* / protein activator of interferon induced protein kinase EIF2AK2*ENSMUSG0000000273140


Protein motifs (from Interpro)
Interpro ID Name
 IPR014720  Double-stranded RNA-binding domain
 IPR028605  RISC-loading complex subunit TRBP2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0030422 production of siRNA involved in RNA interference IEA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0046782 regulation of viral transcription IEA
 biological_processGO:0050689 negative regulation of defense response to virus by host IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0070883 pre-miRNA binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Smarca4tm1.1Grc/Smarca4tm1.1Grc
Genetic Background: involves: 129 * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041415 Dicer1 / dicer 1, ribonuclease III / Q9UPY3*  / complex
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / complex






 

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