ENSG00000139546


Homo sapiens

Features
Gene ID: ENSG00000139546
  
Biological name :TARBP2
  
Synonyms : Q15633 / TARBP2 / TARBP2, RISC loading complex RNA binding subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53500921
Gene end: 53506431
  
Corresponding Affymetrix probe sets: 203677_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458011
Ensembl peptide - ENSP00000449537
Ensembl peptide - ENSP00000450320
Ensembl peptide - ENSP00000266987
Ensembl peptide - ENSP00000377885
Ensembl peptide - ENSP00000416077
Ensembl peptide - ENSP00000447262
Ensembl peptide - ENSP00000447767
Ensembl peptide - ENSP00000447993
Ensembl peptide - ENSP00000448199
Ensembl peptide - ENSP00000448943
Ensembl peptide - ENSP00000448948
NCBI entrez gene - 6895     See in Manteia.
OMIM - 605053
RefSeq - XM_017019911
RefSeq - NM_004178
RefSeq - NM_134323
RefSeq - NM_134324
RefSeq - XM_005269114
RefSeq - XM_005269115
RefSeq - XM_005269117
RefSeq - XM_005269120
RefSeq - XM_005269122
RefSeq - XM_006719581
RefSeq - XM_011538712
RefSeq - XM_017019910
RefSeq Peptide - NP_599151
RefSeq Peptide - NP_599150
RefSeq Peptide - NP_004169
swissprot - F8VW32
swissprot - F8VYK3
swissprot - F8VYK6
swissprot - F8VZ57
swissprot - F8VZZ7
swissprot - H3BV98
swissprot - Q15633
swissprot - F8VP94
swissprot - F8VSA1
swissprot - F8VTT7
Ensembl - ENSG00000139546
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tarbp2ENSDARG00000070471Danio rerio
 TARBP2ENSGALG00000038939Gallus gallus
 P97473ENSMUSG00000023051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKRA / O75569 / protein activator of interferon induced protein kinase EIF2AK2ENSG0000018022840


Protein motifs (from Interpro)
Interpro ID Name
 IPR014720  Double-stranded RNA-binding domain
 IPR028605  RISC-loading complex subunit TRBP2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity TAS
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0010586 miRNA metabolic process TAS
 biological_processGO:0030422 production of siRNA involved in RNA interference IEA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IDA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0045070 positive regulation of viral genome replication IDA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0046782 regulation of viral transcription IEA
 biological_processGO:0050689 negative regulation of defense response to virus by host IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070578 RISC-loading complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0036002 pre-mRNA binding TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0070883 pre-miRNA binding IDA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / complex
 ENSG00000100697 DICER1 / Q9UPY3 / dicer 1, ribonuclease III  / complex






 

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