ENSMUSG00000055884


Mus musculus

Features
Gene ID: ENSMUSG00000055884
  
Biological name :Fancm
  
Synonyms : Fancm / Fanconi anemia group M protein homolog / Q8BGE5
  
Possible biological names infered from orthology : Fanconi anemia complementation group M / Q8IYD8
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C1
Gene start: 65075603
Gene end: 65132058
  
Corresponding Affymetrix probe sets: 10396030 (MoGene1.0st)   1442106_at (Mouse Genome 430 2.0 Array)   1447935_at (Mouse Genome 430 2.0 Array)   1457730_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054797
Ensembl peptide - ENSMUSP00000152885
Ensembl peptide - ENSMUSP00000152854
Ensembl peptide - ENSMUSP00000152396
Ensembl peptide - ENSMUSP00000152223
NCBI entrez gene - 104806     See in Manteia.
MGI - MGI:2442306
RefSeq - XM_017314929
RefSeq - XM_006515344
RefSeq - XM_006515340
RefSeq - NM_178912
RefSeq - XM_006515341
RefSeq - XM_006515342
RefSeq Peptide - NP_849243
swissprot - Q8BGE5
swissprot - A0A1Y7VMA3
swissprot - A0A1Y7VKF2
swissprot - A0A1Y7VKY9
swissprot - A0A1Y7VLB8
Ensembl - ENSMUSG00000055884
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079748.1ENSDARG00000112136Danio rerio
 fancmENSDARG00000103933Danio rerio
 FANCMENSGALG00000031182Gallus gallus
 FANCMENSG00000187790Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dicer1 / dicer 1, ribonuclease III / Q9UPY3*ENSMUSG0000004141512
Ifih1 / Q8R5F7 / Interferon-induced helicase C domain-containing protein 1 / Q9BYX4* / interferon induced with helicase C domain 1*ENSMUSG000000268968
Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*ENSMUSG000000402967
Dhx58 / Q99J87 / Probable ATP-dependent RNA helicase DHX58 / Q96C10* / DExH-box helicase 58*ENSMUSG000000178307


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR006166  ERCC4 domain
 IPR006935  Helicase/UvrB, N-terminal
 IPR010994  RuvA domain 2-like
 IPR011335  Restriction endonuclease type II-like
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031879  Fanconi anemia group M protein, MHF binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IEA
 cellular_componentGO:0071821 FANCM-MHF complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Trp63tm1Brd/Trp63tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp63tm1Brd/Trp63tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025144 Cenpx / Q8C4X1 / Mus musculus centromere protein X (Cenpx), transcript variant 3, mRNA. / A8MT69* / centromere protein X*  / complex
 ENSMUSG00000030493 Faap24 / Q8BHL6 / Fanconi anemia core complex-associated protein 24 / Q9BTP7*  / complex / reaction
 ENSMUSG00000073705 Cenps / Q9D084 / Centromere protein S / Q8N2Z9*  / complex






 

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