ENSMUSG00000026896


Mus musculus

Features
Gene ID: ENSMUSG00000026896
  
Biological name :Ifih1
  
Synonyms : Ifih1 / Interferon-induced helicase C domain-containing protein 1 / Q8R5F7
  
Possible biological names infered from orthology : interferon induced with helicase C domain 1 / Q9BYX4
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 62595798
Gene end: 62646255
  
Corresponding Affymetrix probe sets: 10483110 (MoGene1.0st)   1426276_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028259
Ensembl peptide - ENSMUSP00000108078
NCBI entrez gene - 71586     See in Manteia.
MGI - MGI:1918836
RefSeq - XM_006500187
RefSeq - NM_001164477
RefSeq - NM_027835
RefSeq Peptide - NP_001157949
RefSeq Peptide - NP_082111
swissprot - Q8R5F7
swissprot - D2CGM4
Ensembl - ENSMUSG00000026896
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ifih1ENSDARG00000018553Danio rerio
 IFIH1ENSGALG00000041192Gallus gallus
 IFIH1ENSG00000115267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*ENSMUSG0000004029629
Dhx58 / Q99J87 / Probable ATP-dependent RNA helicase DHX58 / Q96C10* / DExH-box helicase 58*ENSMUSG0000001783028
Dicer1 / dicer 1, ribonuclease III / Q9UPY3*ENSMUSG0000004141517
Fancm / Q8BGE5 / Fanconi anemia group M protein homolog / Q8IYD8* / Fanconi anemia complementation group M*ENSMUSG0000005588416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR006935  Helicase/UvrB, N-terminal
 IPR011029  Death-like domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR021673  RIG-I-like receptor, C-terminal regulatory domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031964  Caspase recruitment domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0016925 protein sumoylation ISO
 biological_processGO:0032727 positive regulation of interferon-alpha production ISO
 biological_processGO:0032728 positive regulation of interferon-beta production ISS
 biological_processGO:0035549 positive regulation of interferon-beta secretion ISO
 biological_processGO:0039530 MDA-5 signaling pathway ISO
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060760 positive regulation of response to cytokine stimulus ISS
 biological_processGO:0071360 cellular response to exogenous dsRNA ISS
 biological_processGO:1902741 positive regulation of interferon-alpha secretion ISO
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion ISO
 biological_processGO:2000778 positive regulation of interleukin-6 secretion ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding ISS
 molecular_functionGO:0003727 single-stranded RNA binding ISS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043021 ribonucleoprotein complex binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

Allelic Composition: Ifih1Rgsc422/Ifih1+,Mavstm1Aki/Mavs+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Ifih1Rgsc422/Ifih1+,Ifnar1tm1Agt/Ifnar1+
Genetic Background: involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki,Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ifih1tm1Aki/Ifih1tm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
Show

Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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