ENSMUSG00000040296


Mus musculus

Features
Gene ID: ENSMUSG00000040296
  
Biological name :Ddx58
  
Synonyms : Ddx58 / Probable ATP-dependent RNA helicase DDX58 / Q6Q899
  
Possible biological names infered from orthology : DExD/H-box helicase 58 / O95786
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 40203773
Gene end: 40239828
  
Corresponding Affymetrix probe sets: 10512067 (MoGene1.0st)   1436562_at (Mouse Genome 430 2.0 Array)   1446457_at (Mouse Genome 430 2.0 Array)   1456890_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115052
Ensembl peptide - ENSMUSP00000042433
NCBI entrez gene - 230073     See in Manteia.
MGI - MGI:2442858
RefSeq - NM_172689
RefSeq Peptide - NP_766277
swissprot - A2AP29
swissprot - Q6Q899
Ensembl - ENSMUSG00000040296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDX58ENSG00000107201Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifih1 / Q8R5F7 / Interferon-induced helicase C domain-containing protein 1 / Q9BYX4* / interferon induced with helicase C domain 1*ENSMUSG0000002689633
Dhx58 / Q99J87 / Probable ATP-dependent RNA helicase DHX58 / Q96C10* / DExH-box helicase 58*ENSMUSG0000001783023
Dicer1 / dicer 1, ribonuclease III / Q9UPY3*ENSMUSG0000004141517
Fancm / Q8BGE5 / Fanconi anemia group M protein homolog / Q8IYD8* / Fanconi anemia complementation group M*ENSMUSG0000005588416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR006935  Helicase/UvrB, N-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR021673  RIG-I-like receptor, C-terminal regulatory domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031964  Caspase recruitment domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009597 detection of virus IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0035549 positive regulation of interferon-beta secretion IEA
 biological_processGO:0039529 RIG-I signaling pathway IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060760 positive regulation of response to cytokine stimulus IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Ub-specific processing proteases
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki,Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki,Ifih1tm1Aki/Ifih1tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx58tm1Aki/Ddx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022867 Usp25 / P57080 / ubiquitin specific peptidase 25 / Q9UHP3*  / complex
 ENSMUSG00000032905 Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12 / O94817* / autophagy related 12*  / reaction / complex
 ENSMUSG00000038160 Atg5 / Q99J83 / Autophagy protein 5 / Q9H1Y0* / autophagy related 5*  / complex / reaction
 ENSMUSG00000037523 Mavs / Q8VCF0 / Mitochondrial antiviral-signaling protein / Q7Z434*  / reaction / complex
 ENSMUSG00000053483 Usp21 / ubiquitin specific peptidase 21 / Q9UK80*  / complex






 

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