ENSMUSG00000032905


Mus musculus

Features
Gene ID: ENSMUSG00000032905
  
Biological name :Atg12
  
Synonyms : Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12
  
Possible biological names infered from orthology : autophagy related 12 / O94817
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: C
Gene start: 46732417
Gene end: 46741579
  
Corresponding Affymetrix probe sets: 10458834 (MoGene1.0st)   1439457_x_at (Mouse Genome 430 2.0 Array)   1451746_a_at (Mouse Genome 430 2.0 Array)   1451747_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038489
NCBI entrez gene - 67526     See in Manteia.
MGI - MGI:1914776
RefSeq - NM_026217
RefSeq Peptide - NP_080493
swissprot - Q9CQY1
Ensembl - ENSMUSG00000032905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg12ENSDARG00000069545Danio rerio
 ATG12ENSGALG00000002345Gallus gallus
 ATG12ENSG00000145782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007242  Ubiquitin-like protein Atg12
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy TAS
 biological_processGO:0044804 autophagy of nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 cellular_componentGO:0034274 Atg12-Atg5-Atg16 complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019776 Atg8 ligase activity IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

Allelic Composition: Atg12tm1.2Jdth/Atg12tm1.2Jdth
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026289 Q8C0J2 / Atg16l1 / autophagy related 16-like 1 (S. cerevisiae) / Q676U5* / autophagy related 16 like 1*  / reaction / complex
 ENSMUSG00000021619 Atg10 / autophagy related 10 / Q9H0Y0*  / complex
 ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1*  / complex / reaction
 ENSMUSG00000030314 Atg7 / Q9D906 / Ubiquitin-like modifier-activating enzyme ATG7 / O95352* / autophagy related 7*  / reaction / complex
 ENSMUSG00000038160 Atg5 / Q99J83 / Autophagy protein 5 / Q9H1Y0* / autophagy related 5*  / reaction / complex
 ENSMUSG00000040296 Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*  / complex / reaction
 ENSMUSG00000037523 Mavs / Q8VCF0 / Mitochondrial antiviral-signaling protein / Q7Z434*  / complex
 ENSMUSG00000029578 Wipi2 / Q80W47 / WD repeat domain, phosphoinositide interacting 2 / Q9Y4P8*  / complex / reaction
 ENSMUSG00000032905 Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12 / O94817* / autophagy related 12*  / complex / reaction
 ENSMUSG00000031812 Q9CQV6 / Map1lc3b / Microtubule-associated proteins 1A/1B light chain 3B / A6NCE7* / Q9GZQ8* / MAP1LC3B2* / microtubule associated protein 1 light chain 3 beta* / microtubule associated pr...  / reaction / complex
 ENSMUSG00000027602 Q91VR7 / Map1lc3a / Microtubule-associated proteins 1A/1B light chain 3A / Q9H492* / microtubule associated protein 1 light chain 3 alpha*  / reaction / complex






 

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