ENSG00000145782


Homo sapiens

Features
Gene ID: ENSG00000145782
  
Biological name :ATG12
  
Synonyms : ATG12 / autophagy related 12 / O94817
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q22.3
Gene start: 115828200
Gene end: 115841858
  
Corresponding Affymetrix probe sets: 204833_at (Human Genome U133 Plus 2.0 Array)   213026_at (Human Genome U133 Plus 2.0 Array)   213930_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368913
Ensembl peptide - ENSP00000425164
Ensembl peptide - ENSP00000425948
Ensembl peptide - ENSP00000425277
Ensembl peptide - ENSP00000424529
Ensembl peptide - ENSP00000425107
NCBI entrez gene - 9140     See in Manteia.
OMIM - 609608
RefSeq - NM_004707
RefSeq - NM_001277783
RefSeq Peptide - NP_001264712
RefSeq Peptide - NP_004698
swissprot - D6RB14
swissprot - O94817
swissprot - H0Y9W4
swissprot - H0YA29
swissprot - H7BYD7
Ensembl - ENSG00000145782
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg12ENSDARG00000069545Danio rerio
 ATG12ENSGALG00000002345Gallus gallus
 Atg12ENSMUSG00000032905Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007242  Ubiquitin-like protein Atg12
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0044804 autophagy of nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0034045 phagophore assembly site membrane IBA
 cellular_componentGO:0034274 Atg12-Atg5-Atg16 complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019776 Atg8 ligase activity IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000152348 ATG10 / Q9H0Y0 / autophagy related 10  / reaction / complex
 ENSG00000140941 Q9GZQ8 / MAP1LC3B / microtubule associated protein 1 light chain 3 beta  / reaction / complex
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / reaction / complex
 ENSG00000197548 ATG7 / O95352 / autophagy related 7  / reaction / complex
 ENSG00000085978 Q676U5 / ATG16L1 / autophagy related 16 like 1  / complex / reaction
 ENSG00000101460 Q9H492 / MAP1LC3A / microtubule associated protein 1 light chain 3 alpha  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex
 ENSG00000069509 FUNDC1 / Q8IVP5 / FUN14 domain containing 1  / reaction / complex
 ENSG00000157954 WIPI2 / Q9Y4P8 / WD repeat domain, phosphoinositide interacting 2  / complex / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / reaction / complex
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / complex






 

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