ENSG00000088888


Homo sapiens

Features
Gene ID: ENSG00000088888
  
Biological name :MAVS
  
Synonyms : MAVS / mitochondrial antiviral signaling protein / Q7Z434
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p13
Gene start: 3846799
Gene end: 3876123
  
Corresponding Affymetrix probe sets: 220305_at (Human Genome U133 Plus 2.0 Array)   226495_at (Human Genome U133 Plus 2.0 Array)   229741_at (Human Genome U133 Plus 2.0 Array)   231829_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401980
Ensembl peptide - ENSP00000413749
NCBI entrez gene - 57506     See in Manteia.
OMIM - 609676
RefSeq - NM_001206491
RefSeq - NM_020746
RefSeq Peptide - NP_001193420
RefSeq Peptide - NP_065797
swissprot - Q7Z434
Ensembl - ENSG00000088888
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mavsENSDARG00000069733Danio rerio
 MAVSENSGALG00000040428Gallus gallus
 MavsENSMUSG00000037523Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026148  Mitochondrial antiviral-signalling protein
 IPR031964  Caspase recruitment domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032727 positive regulation of interferon-alpha production IMP
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IDA
 biological_processGO:0035549 positive regulation of interferon-beta secretion IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IDA
 biological_processGO:0060760 positive regulation of response to cytokine stimulus IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IMP
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production IDA
 biological_processGO:0071660 positive regulation of IP-10 production IDA
 biological_processGO:1900063 regulation of peroxisome organization IMP
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IMP
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0050700 CARD domain binding IPI


Pathways (from Reactome)
Pathway description
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ovarian tumor domain proteases
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000068308 OTUD5 / Q96G74 / OTU deubiquitinase 5  / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / reaction / complex
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000003400 CASP10 / Q92851 / caspase 10  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / complex / reaction
 ENSG00000160703 NLRX1 / Q86UT6 / NLR family member X1  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000197111 PCBP2 / Q15366 / poly(rC) binding protein 2  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000095015 MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000078747 ITCH / Q96J02 / itchy E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex






 

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