ENSG00000057663


Homo sapiens

Features
Gene ID: ENSG00000057663
  
Biological name :ATG5
  
Synonyms : ATG5 / autophagy related 5 / Q9H1Y0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 106045423
Gene end: 106325791
  
Corresponding Affymetrix probe sets: 202511_s_at (Human Genome U133 Plus 2.0 Array)   202512_s_at (Human Genome U133 Plus 2.0 Array)   210639_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000490221
Ensembl peptide - ENSP00000343313
Ensembl peptide - ENSP00000483135
Ensembl peptide - ENSP00000490376
Ensembl peptide - ENSP00000495958
Ensembl peptide - ENSP00000490493
Ensembl peptide - ENSP00000353884
Ensembl peptide - ENSP00000358066
Ensembl peptide - ENSP00000358072
NCBI entrez gene - 9474     See in Manteia.
OMIM - 604261
RefSeq - NM_004849
RefSeq - NM_001286106
RefSeq - NM_001286107
RefSeq - NM_001286108
RefSeq - NM_001286111
RefSeq Peptide - NP_001273035
RefSeq Peptide - NP_004840
RefSeq Peptide - NP_001273040
RefSeq Peptide - NP_001273037
RefSeq Peptide - NP_001273036
swissprot - Q9H1Y0
swissprot - A0A1B0GUS1
swissprot - A0A1B0GV54
swissprot - A9UGY9
swissprot - L7UMD8
swissprot - L7UQJ2
swissprot - Q7Z3H3
Ensembl - ENSG00000057663
  
Related genetic diseases (OMIM): 617584 - ?Spinocerebellar ataxia, autosomal recessive 25, 617584
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg5ENSDARG00000023396Danio rerio
 ATG5ENSGALG00000015387Gallus gallus
 Atg5ENSMUSG00000038160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007239  Autophagy-related protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002739 regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009620 response to fungus IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0019725 cellular homeostasis IEA
 biological_processGO:0019883 antigen processing and presentation of endogenous antigen IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0035973 aggrephagy IMP
 biological_processGO:0039689 negative stranded viral RNA replication IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043687 post-translational protein modification ISS
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0048840 otolith development IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0061739 protein lipidation involved in autophagosome assembly IEA
 biological_processGO:0070257 positive regulation of mucus secretion IEA
 biological_processGO:0071500 cellular response to nitrosative stress IEA
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IGI
 biological_processGO:1902017 regulation of cilium assembly IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 cellular_componentGO:0034274 Atg12-Atg5-Atg16 complex IBA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019776 Atg8 ligase activity IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / reaction / complex
 ENSG00000152348 ATG10 / Q9H0Y0 / autophagy related 10  / complex / reaction
 ENSG00000140941 Q9GZQ8 / MAP1LC3B / microtubule associated protein 1 light chain 3 beta  / reaction / complex
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / complex / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / complex / reaction
 ENSG00000101460 Q9H492 / MAP1LC3A / microtubule associated protein 1 light chain 3 alpha  / reaction / complex
 ENSG00000157954 WIPI2 / Q9Y4P8 / WD repeat domain, phosphoinositide interacting 2  / reaction / complex
 ENSG00000085978 Q676U5 / ATG16L1 / autophagy related 16 like 1  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000069509 FUNDC1 / Q8IVP5 / FUN14 domain containing 1  / reaction / complex
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / complex






 

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