ENSG00000101460


Homo sapiens

Features
Gene ID: ENSG00000101460
  
Biological name :MAP1LC3A
  
Synonyms : MAP1LC3A / microtubule associated protein 1 light chain 3 alpha / Q9H492
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.22
Gene start: 34546854
Gene end: 34560345
  
Corresponding Affymetrix probe sets: 224378_x_at (Human Genome U133 Plus 2.0 Array)   227219_x_at (Human Genome U133 Plus 2.0 Array)   232011_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353886
Ensembl peptide - ENSP00000363970
Ensembl peptide - ENSP00000380821
NCBI entrez gene - 84557     See in Manteia.
OMIM - 601242
RefSeq - XM_011529085
RefSeq - NM_032514
RefSeq - NM_181509
RefSeq - XM_011529083
RefSeq - XM_011529084
RefSeq Peptide - NP_115903
RefSeq Peptide - NP_852610
swissprot - Q9H492
Ensembl - ENSG00000101460
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map1lc3aENSDARG00000033609Danio rerio
 ENSGALG00000038721Gallus gallus
 Q91VR7ENSMUSG00000027602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9GZQ8 / MAP1LC3B / microtubule associated protein 1 light chain 3 betaENSG0000014094172
A6NCE7 / MAP1LC3B2 / microtubule associated protein 1 light chain 3 beta 2ENSG0000025810271
Q9BXW4 / MAP1LC3C / microtubule associated protein 1 light chain 3 gammaENSG0000019776950
P60520 / GABARAPL2 / GABA type A receptor associated protein like 2ENSG0000003471334
Q9H0R8 / GABARAPL1 / GABA type A receptor associated protein like 1ENSG0000013911230
O95166 / GABARAP / GABA type A receptor-associated proteinENSG0000017029627


Protein motifs (from Interpro)
Interpro ID Name
 IPR004241  Autophagy protein Atg8 ubiquitin-like
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly ISS
 biological_processGO:0000422 autophagy of mitochondrion IGI
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010040 response to iron(II) ion IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0016236 macroautophagy IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0097352 autophagosome maturation IDA
 cellular_componentGO:0000421 autophagosome membrane TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0044754 autolysosome IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / complex / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / reaction / complex
 ENSG00000069509 FUNDC1 / Q8IVP5 / FUN14 domain containing 1  / complex / reaction






 

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