ENSG00000085978


Homo sapiens

Features
Gene ID: ENSG00000085978
  
Biological name :ATG16L1
  
Synonyms : ATG16L1 / autophagy related 16 like 1 / Q676U5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.1
Gene start: 233210051
Gene end: 233295674
  
Corresponding Affymetrix probe sets: 220521_s_at (Human Genome U133 Plus 2.0 Array)   232612_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375872
Ensembl peptide - ENSP00000412046
Ensembl peptide - ENSP00000409215
Ensembl peptide - ENSP00000398773
Ensembl peptide - ENSP00000397512
Ensembl peptide - ENSP00000375876
Ensembl peptide - ENSP00000375875
Ensembl peptide - ENSP00000375873
Ensembl peptide - ENSP00000318259
Ensembl peptide - ENSP00000362625
NCBI entrez gene - 55054     See in Manteia.
OMIM - 610767
RefSeq - XM_006712608
RefSeq - NM_001190266
RefSeq - NM_001190267
RefSeq - NM_017974
RefSeq - NM_030803
RefSeq - NM_198890
RefSeq - XM_005246082
RefSeq - XM_005246084
RefSeq - XM_005246086
RefSeq Peptide - NP_942593
RefSeq Peptide - NP_001177195
RefSeq Peptide - NP_001177196
RefSeq Peptide - NP_060444
RefSeq Peptide - NP_110430
swissprot - C9JAY7
swissprot - C9J8C6
swissprot - C9J1B2
swissprot - A0A024R494
swissprot - Q676U5
swissprot - E7EVC7
swissprot - C9JK97
swissprot - F8WAF9
Ensembl - ENSG00000085978
  
Related genetic diseases (OMIM): 611081 - {Inflammatory bowel disease (Crohn disease) 10}, 611081
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg16l1ENSDARG00000099430Danio rerio
 ATG16L1ENSGALG00000001619Gallus gallus
 Q8C0J2ENSMUSG00000026289Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NAA4 / ATG16L2 / autophagy related 16 like 2ENSG0000016801039
TAF5L / O75529 / TATA-box binding protein associated factor 5 likeENSG0000013580115
TAF5 / Q15542 / TATA-box binding protein associated factor 5ENSG0000014883515
WDR83 / Q9BRX9 / WD repeat domain 83ENSG0000012315412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013923  Autophagy-related protein 16
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0034497 protein localization to phagophore assembly site IEA
 biological_processGO:0039689 negative stranded viral RNA replication IBA
 biological_processGO:0051260 protein homooligomerization NAS
 biological_processGO:0061739 protein lipidation involved in autophagosome assembly IEA
 biological_processGO:0098792 xenophagy IEA
 cellular_componentGO:0000421 autophagosome membrane IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019787 ubiquitin-like protein transferase activity TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000085978 Q676U5 / ATG16L1 / autophagy related 16 like 1  / complex / reaction
 ENSG00000144848 ATG3 / Q9NT62 / autophagy related 3  / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / complex / reaction
 ENSG00000157954 WIPI2 / Q9Y4P8 / WD repeat domain, phosphoinositide interacting 2  / complex / reaction
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / complex / reaction






 

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