MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000479 | abnormal intestinal cell | "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ppp1cctm1Lex/Ppp1cctm1Lex,Tg(Stra8-icre)1Reb/0 Genetic Background: involves: 129S/SvEvBrd * FVB/NJ
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MP:0001858 | intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dnah11b2b1468.2Clo/Dnah11b2b1468.2Clo Genetic Background: C57BL/6J-Dnah11b2b1468.2Clo
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Txlngtm1.2Star/Txlng+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C57BL/10
Allelic Composition: Atg16l1tm1.1Mvlc/Atg16l1tm1.1Mvlc Genetic Background: C57BL/6-Atg16l1tm1.1Mvlc
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MP:0002965 | hyperalbuminemia | "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH
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MP:0003686 | abnormal eye muscle morphology | "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0004843 | abnormal Paneth cell morphology | "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Retnlbtm1Mer/Retnlbtm1Mer Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0005561 | increased mean corpuscular hemoglobin | "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH
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MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C57BL/10
Allelic Composition: Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi,Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrj
Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Atg16l1tm1.1Mvlc/Atg16l1tm1.1Mvlc Genetic Background: C57BL/6-Atg16l1tm1.1Mvlc
Allelic Composition: Atg16l1tm2.1Mvlc/Atg16l1tm2.1Mvlc,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C57BL/10
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MP:0008588 | abnormal circulating interleukin level | "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0008641 | increased circulating interleukin-1 beta level | "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Atg16l1tm1.1Mvlc/Atg16l1tm1.1Mvlc Genetic Background: C57BL/6-Atg16l1tm1.1Mvlc
Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C57BL/10
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MP:0008684 | increased interleukin-18 secretion | "increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C57BL/10
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MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0008721 | abnormal chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0008882 | abnormal enterocyte physiology | "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
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MP:0008923 | thoracoschisis | "congenital fissure of the chest wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0009481 | cecum inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0009482 | ileum inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
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MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010439 | abnormal hepatic vein morphology | "any structural anomaly of the veins that drain blood from the liver and terminate in three large openings to the inferior vena cava below the diaphragm and into smaller openings in more inferior positions" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010490 | abnormal inferior vena cava valve morphology | "any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0011078 | increased macrophage cytokine production | "greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg16l1tm1.1Mvlc/Atg16l1tm1.1Mvlc Genetic Background: C57BL/6-Atg16l1tm1.1Mvlc
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C57BL/10
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MP:0013486 | decreased Paneth cell number | "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi,Tg(Vil1-cre)997Gum/? Genetic Background: involves: C57BL/6J * C57BL/6N * SJL
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MP:0013830 | abnormal intrathoracic topology of vagus nerve | "abnormal position of the vagus nerve in the intrathoracic region" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013835 | absent hypoglossal nerve | "absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013836 | abnormal hypoglossal nerve topology | "abnormal position of the hypoglossal nerve " [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013840 | absent segment of posterior cerebral artery | "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013848 | subcutaneous edema | "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013876 | absent ductus venosus valve | "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013936 | abnormal thymus topology | "of the primary lymphoid organ that is required for maturation of T cells and secretion of thymosins, hormones that stimulate the development of antibodies" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013970 | absent connection between subcutaneous lymph vessels and lymph sac | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013971 | blood in lymph vessels | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013986 | abnormal vitelline vein topology | "abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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