ENSMUSG00000005150


Mus musculus

Features
Gene ID: ENSMUSG00000005150
  
Biological name :Wdr83
  
Synonyms : Q9DAJ4 / Wdr83 / WD repeat domain containing 83
  
Possible biological names infered from orthology : Q9BRX9 / WD repeat domain 83
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 85075035
Gene end: 85081306
  
Corresponding Affymetrix probe sets: 10580309 (MoGene1.0st)   1418732_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122127
Ensembl peptide - ENSMUSP00000122737
Ensembl peptide - ENSMUSP00000091048
Ensembl peptide - ENSMUSP00000121568
NCBI entrez gene - 67836     See in Manteia.
MGI - MGI:1915086
RefSeq - NM_026399
RefSeq Peptide - NP_080675
swissprot - D6RGR4
swissprot - F7C259
swissprot - Q9DAJ4
Ensembl - ENSMUSG00000005150
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr83ENSDARG00000041600Danio rerio
 WDR83ENSG00000123154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6KAU8 / Atg16l2 / autophagy related 16-like 2 (S. cerevisiae) / Q8NAA4* / autophagy related 16 like 2*ENSMUSG0000004776721
Q8C0J2 / Atg16l1 / autophagy related 16-like 1 (S. cerevisiae) / Q676U5* / autophagy related 16 like 1*ENSMUSG0000002628921
Taf5 / TATA-box binding protein associated factor 5 / Q15542*ENSMUSG0000002504921
Taf5l / Q91WQ5 / Mus musculus TATA-box binding protein associated factor 5 like (Taf5l), transcript variant 2, mRNA. / O75529* / TATA-box binding protein associated factor 5 like*ENSMUSG0000003869719


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000375 RNA splicing, via transesterification reactions ISO
 biological_processGO:0000398 mRNA splicing, via spliceosome ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005681 spliceosomal complex ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011372 decreased renal tubule apoptosis "decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000028062 Q9JHS3 / Lamtor2 / Ragulator complex protein LAMTOR2 / Q9Y2Q5* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2*  / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / reaction / complex
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex / reaction
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / complex






 

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