ENSMUSG00000028062


Mus musculus

Features
Gene ID: ENSMUSG00000028062
  
Biological name :Lamtor2
  
Synonyms : Lamtor2 / Q9JHS3 / Ragulator complex protein LAMTOR2
  
Possible biological names infered from orthology : late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9Y2Q5
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 88549819
Gene end: 88553074
  
Corresponding Affymetrix probe sets: 10499420 (MoGene1.0st)   1422797_at (Mouse Genome 430 2.0 Array)   1435729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112936
Ensembl peptide - ENSMUSP00000029698
NCBI entrez gene - 83409     See in Manteia.
MGI - MGI:1932697
RefSeq - NM_031248
RefSeq Peptide - NP_112538
swissprot - D3YTS4
swissprot - Q9JHS3
Ensembl - ENSMUSG00000028062
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamtor2ENSDARG00000039872Danio rerio
 LAMTOR2ENSGALG00000029881Gallus gallus
 Q9Y2Q5ENSG00000116586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004942  Roadblock/LAMTOR2 domain
 IPR037587  Ragulator complex protein LAMTOR2-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0071986 Ragulator complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
MAP2K and MAPK activation
Neutrophil degranulation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm2Bird/Mecp2+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm2Bird/Mecp2+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mecp2tm2Bird/Mecp2+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Lamtor2tm1.1Lah/Lamtor2tm1.1Lah,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000005150 Wdr83 / Q9DAJ4 / WD repeat domain containing 83 / Q9BRX9* / WD repeat domain 83*  / complex
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / reaction / complex
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex / reaction
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction






 

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