ENSMUSG00000035027


Mus musculus

Features
Gene ID: ENSMUSG00000035027
  
Biological name :Map2k2
  
Synonyms : Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / Q63932
  
Possible biological names infered from orthology : AC011005.1 / mitogen-activated protein kinase kinase 2 / P36507
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81105915
Gene end: 81133975
  
Corresponding Affymetrix probe sets: 10364971 (MoGene1.0st)   1415974_at (Mouse Genome 430 2.0 Array)   1460636_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137918
Ensembl peptide - ENSMUSP00000121111
Ensembl peptide - ENSMUSP00000151546
Ensembl peptide - ENSMUSP00000151784
Ensembl peptide - ENSMUSP00000100968
Ensembl peptide - ENSMUSP00000117567
NCBI entrez gene - 26396     See in Manteia.
MGI - MGI:1346867
RefSeq - XM_006513684
RefSeq - NM_001347144
RefSeq - NM_023138
RefSeq - XM_006513682
RefSeq - XM_006513683
RefSeq Peptide - NP_075627
RefSeq Peptide - NP_001334073
swissprot - D3Z446
swissprot - M0QWN2
swissprot - A0A1W2P7V9
swissprot - A0A1W2P769
swissprot - Q91YS7
swissprot - Q63932
Ensembl - ENSMUSG00000035027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k2aENSDARG00000006609Danio rerio
 map2k2bENSDARG00000068918Danio rerio
 MAP2K2ENSGALG00000001267Gallus gallus
 AC011005.1ENSG00000230626Homo sapiens
 MAP2K2ENSG00000126934Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493680
Map2k5 / Q9WVS7 / Dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / mitogen-activated protein kinase kinase 5*ENSMUSG0000005844438
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000000294833
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000010906133
Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*ENSMUSG0000002062332
Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*ENSMUSG0000003335232
Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*ENSMUSG0000001893231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0032872 regulation of stress-activated MAPK cascade TAS
 biological_processGO:0036289 peptidyl-serine autophosphorylation ISO
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0048679 regulation of axon regeneration IGI
 biological_processGO:0050772 positive regulation of axonogenesis IGI
 biological_processGO:0060324 face development IGI
 biological_processGO:0060425 lung morphogenesis IGI
 biological_processGO:0060440 trachea formation IGI
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis IGI
 biological_processGO:0070371 ERK1 and ERK2 cascade IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0090170 regulation of Golgi inheritance TAS
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
 biological_processGO:2000147 positive regulation of cell motility IDA
 biological_processGO:2000641 regulation of early endosome to late endosome transport TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005770 late endosome TAS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005925 focal adhesion TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097110 scaffold protein binding ISO


Pathways (from Reactome)
Pathway description
MAPK1 (ERK2) activation
Signal transduction by L1
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001215 skin hypoplasia "underdevelopment of the cutis, usually due to a deficiency in the number of cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(KRT14-RAF1/ESR1)1Pkha/?
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Map2k2tm1a(EUCOMM)Wtsi/Map2k2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Map2k2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Map2k2tm1a(EUCOMM)Wtsi/Map2k2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Map2k2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Bbd/Kras+,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hivep3tm3Glm/Hivep3+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * SJL * SJL/J

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Krastm1Bbd/Kras+,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map2k2tm1a(EUCOMM)Wtsi/Map2k2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Map2k2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0010283 decreased classified tumor incidence "less than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000028062 Q9JHS3 / Lamtor2 / Ragulator complex protein LAMTOR2 / Q9Y2Q5* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2*  / complex / reaction
 ENSMUSG00000040717 Il17rd / Q8JZL1 / Interleukin-17 receptor D / Q8NFM7*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / complex / reaction
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / complex / reaction
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / complex
 ENSMUSG00000005150 Wdr83 / Q9DAJ4 / WD repeat domain containing 83 / Q9BRX9* / WD repeat domain 83*  / complex / reaction
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / complex / reaction






 

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