ENSMUSG00000002948


Mus musculus

Features
Gene ID: ENSMUSG00000002948
  
Biological name :Map2k7
  
Synonyms : Dual specificity mitogen-activated protein kinase kinase 7 / Map2k7 / Q8CE90
  
Possible biological names infered from orthology : mitogen-activated protein kinase kinase 7 / O14733
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 4238740
Gene end: 4247897
  
Corresponding Affymetrix probe sets: 10569927 (MoGene1.0st)   1425393_a_at (Mouse Genome 430 2.0 Array)   1425512_at (Mouse Genome 430 2.0 Array)   1425513_at (Mouse Genome 430 2.0 Array)   1451736_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146485
Ensembl peptide - ENSMUSP00000106626
Ensembl peptide - ENSMUSP00000106627
Ensembl peptide - ENSMUSP00000003027
Ensembl peptide - ENSMUSP00000054512
Ensembl peptide - ENSMUSP00000106622
Ensembl peptide - ENSMUSP00000106623
Ensembl peptide - ENSMUSP00000106624
NCBI entrez gene - 26400     See in Manteia.
MGI - MGI:1346871
RefSeq - NM_001164172
RefSeq - NM_001042557
RefSeq - NM_001291777
RefSeq - NM_001291778
RefSeq - NM_001291783
RefSeq - NM_011944
RefSeq Peptide - NP_001278712
RefSeq Peptide - NP_036074
RefSeq Peptide - NP_001157644
RefSeq Peptide - NP_001278706
RefSeq Peptide - NP_001036022
RefSeq Peptide - NP_001278707
swissprot - A0A140LHN8
swissprot - Q8CE90
Ensembl - ENSMUSG00000002948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k7ENSDARG00000008279Danio rerio
 MAP2K7ENSG00000076984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000010906194
Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*ENSMUSG0000003335237
Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*ENSMUSG0000002062333
Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*ENSMUSG0000001893230
Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*ENSMUSG0000003502728
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493627
Map2k5 / Q9WVS7 / Dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / mitogen-activated protein kinase kinase 5*ENSMUSG0000005844426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006970 response to osmotic stress ISO
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009408 response to heat ISO
 biological_processGO:0009411 response to UV ISO
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase ISO
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0051403 stress-activated MAPK cascade ISO
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 biological_processGO:1904355 positive regulation of telomere capping ISO
 biological_processGO:2000671 regulation of motor neuron apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity ISO
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008545 JUN kinase kinase activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016909 SAP kinase activity IDA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020366 Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*  / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction
 ENSMUSG00000021754 Map3k1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*  / reaction






 

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