ENSMUSG00000018932


Mus musculus

Features
Gene ID: ENSMUSG00000018932
  
Biological name :Map2k3
  
Synonyms : Map2k3 / mitogen-activated protein kinase kinase 3 / O09110
  
Possible biological names infered from orthology : P46734
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 60932033
Gene end: 60952811
  
Corresponding Affymetrix probe sets: 10376733 (MoGene1.0st)   1425456_a_at (Mouse Genome 430 2.0 Array)   1451714_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019076
Ensembl peptide - ENSMUSP00000114430
NCBI entrez gene - 26397     See in Manteia.
MGI - MGI:1346868
RefSeq - XM_006533368
RefSeq - NM_008928
RefSeq Peptide - NP_032954
swissprot - O09110
swissprot - Q5SWN9
swissprot - A0A0R4J1Q6
Ensembl - ENSMUSG00000018932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K3ENSGALG00000041285Gallus gallus
 MAP2K3ENSG00000034152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*ENSMUSG0000002062374
Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*ENSMUSG0000003335251
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000010906141
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000000294841
Map2k5 / Q9WVS7 / Dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / mitogen-activated protein kinase kinase 5*ENSMUSG0000005844438
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493636
Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*ENSMUSG0000003502736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042035 regulation of cytokine biosynthetic process IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060048 cardiac muscle contraction IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IMP
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Pycardtm1Flv

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Pycardtm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000032577 Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction
 ENSMUSG00000071369 Map3k5 / O35099 / Mitogen-activated protein kinase kinase kinase 5 / Q99683*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr