ENSMUSG00000032577


Mus musculus

Features
Gene ID: ENSMUSG00000032577
  
Biological name :Mapkapk3
  
Synonyms : Mapkapk3 / MAP kinase-activated protein kinase 3 / Q3UMW7
  
Possible biological names infered from orthology : mitogen-activated protein kinase-activated protein kinase 3 / Q16644
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 107254927
Gene end: 107289877
  
Corresponding Affymetrix probe sets: 10596637 (MoGene1.0st)   1434815_a_at (Mouse Genome 430 2.0 Array)   1437494_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035194
Ensembl peptide - ENSMUSP00000120848
Ensembl peptide - ENSMUSP00000141342
NCBI entrez gene - 102626     See in Manteia.
MGI - MGI:2143163
RefSeq - XM_006511619
RefSeq - NM_001316691
RefSeq - NM_178907
RefSeq - XM_006511616
RefSeq - XM_006511617
RefSeq - XM_006511618
RefSeq Peptide - NP_001303620
RefSeq Peptide - NP_849238
swissprot - B0QZU6
swissprot - Q3UMW7
Ensembl - ENSMUSG00000032577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk3ENSDARG00000111612Danio rerio
 MAPKAPK3ENSGALG00000002283Gallus gallus
 Q16644ENSG00000114738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*ENSMUSG0000001652865
O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*ENSMUSG0000002945439
Gm42878 / Q8IW41* / MAPKAPK5* / mitogen-activated protein kinase-activated protein kinase 5*ENSMUSG0000010534039
Mknk1 / MAP kinase-interacting serine/threonine kinase 1 / Q9BUB5*ENSMUSG0000002870831
Mknk2 / Q8CDB0 / MAP kinase-interacting serine/threonine-protein kinase 2 / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2*ENSMUSG0000002019031


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0002224 toll-like receptor signaling pathway IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0034097 response to cytokine ISS
 biological_processGO:0044351 macropinocytosis IMP
 biological_processGO:0046777 protein autophosphorylation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
Oxidative Stress Induced Senescence
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex / reaction
 ENSMUSG00000018932 Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*  / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction / complex






 

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