ENSMUSG00000016528


Mus musculus

Features
Gene ID: ENSMUSG00000016528
  
Biological name :Mapkapk2
  
Synonyms : Mapkapk2 / MAP kinase-activated protein kinase 2 / P49138
  
Possible biological names infered from orthology : mitogen-activated protein kinase-activated protein kinase 2 / P49137
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 131053700
Gene end: 131097826
  
Corresponding Affymetrix probe sets: 10357579 (MoGene1.0st)   1426648_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141124
Ensembl peptide - ENSMUSP00000016672
NCBI entrez gene - 17164     See in Manteia.
MGI - MGI:109298
RefSeq - NM_008551
RefSeq Peptide - NP_032577
swissprot - A0A087WSN7
swissprot - P49138
swissprot - Q3U2P8
Ensembl - ENSMUSG00000016528
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk2aENSDARG00000002552Danio rerio
 mapkapk2bENSDARG00000018530Danio rerio
 MAPKAPK2ENSGALG00000000883Gallus gallus
 P49137ENSG00000162889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*ENSMUSG0000003257765
O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*ENSMUSG0000002945441
Gm42878 / Q8IW41* / MAPKAPK5* / mitogen-activated protein kinase-activated protein kinase 5*ENSMUSG0000010534040
Mknk2 / Q8CDB0 / MAP kinase-interacting serine/threonine-protein kinase 2 / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2*ENSMUSG0000002019030
Mknk1 / MAP kinase-interacting serine/threonine kinase 1 / Q9BUB5*ENSMUSG0000002870829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032675 regulation of interleukin-6 production IMP
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038066 p38MAPK cascade IMP
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IMP
 biological_processGO:0044351 macropinocytosis IMP
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048255 mRNA stabilization IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
CREB phosphorylation
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Krastm4Tyj/Kras+,Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S/SvEv * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Sall4tm1Brd/Sall4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Tg(Ins-Igf2)1Fbos/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0008243 abnormal foam cell morphology "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction / complex
 ENSMUSG00000025701 Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000021127 P23950 / Zfp36l1 / zinc finger protein 36, C3H type-like 1 / Q07352* / ZFP36 ring finger protein like 1*  / reaction
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000018932 Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*  / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction / complex






 

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