ENSGALG00000000883


Gallus gallus

Features
Gene ID: ENSGALG00000000883
  
Biological name :MAPKAPK2
  
Synonyms : MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2
  
Possible biological names infered from orthology : MAP kinase-activated protein kinase 2 / P49137 / P49138
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 2534865
Gene end: 2552591
  
Corresponding Affymetrix probe sets: Gga.12405.1.S1_x_at (Chicken Array)   Gga.12405.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001295
NCBI entrez gene - 419847     See in Manteia.
RefSeq - XM_015299062
swissprot - F1NCY7
Ensembl - ENSGALG00000000883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk2aENSDARG00000002552Danio rerio
 mapkapk2bENSDARG00000018530Danio rerio
 P49137ENSG00000162889Homo sapiens
 P49138ENSMUSG00000016528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPKAPK3 / Gallus gallus mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), mRNA. / Q16644* / Q3UMW7* / MAP kinase-activated protein kinase 3 * / mitogen-activated prot...ENSGALG0000000228367
MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41* / O54992* / Gm42878* / MAP kinase-activated protein kinase 5 *ENSGALG0000000474340
MKNK1 / MAP kinase interacting serine/threonine kinase 1 / Q9BUB5*ENSGALG0000001044030
MKNK2 / MAP kinase interacting serine/threonine kinase 2 / Q8CDB0* / Q9HBH9* / MAP kinase-interacting serine/threonine-protein kinase 2 *ENSGALG0000000384529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017987  Wilm"s tumour protein
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032675 regulation of interleukin-6 production IEA
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0044351 macropinocytosis IEA
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
CREB phosphorylation
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005857 ALOX5* / P09917* / P48999* / arachidonate 5-lipoxygenase*  / reaction
 ENSGALG00000039228 ZFP36L1 / Gallus gallus ZFP36 ring finger protein like 1 (ZFP36L1), mRNA. / Q07352* / P23950* / ZFP36 ring finger protein like 1* / zinc finger protein 36, C3H type-like 1*  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex / reaction
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex / reaction
 ENSGALG00000008494 CREB1 / P16220* / Q01147* / cAMP responsive element binding protein 1* / Cyclic AMP-responsive element-binding protein 1 *  / reaction
 ENSGALG00000004370 MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*  / reaction
 ENSGALG00000041285 MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*  / reaction






 

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