ENSGALG00000041285


Gallus gallus

Features
Gene ID: ENSGALG00000041285
  
Biological name :MAP2K3
  
Synonyms : MAP2K3 / mitogen-activated protein kinase kinase 3
  
Possible biological names infered from orthology : O09110 / P46734
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 4510613
Gene end: 4536085
  
Corresponding Affymetrix probe sets: Gga.17383.1.S1_at (Chicken Array)   Gga.17897.1.S1_s_at (Chicken Array)   GgaAffx.12031.1.S1_at (Chicken Array)   GgaAffx.12031.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050706
NCBI entrez gene - 416496     See in Manteia.
RefSeq - NM_001012787
RefSeq Peptide - NP_001012805
swissprot - A0A1D5PD64
Ensembl - ENSGALG00000041285
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K3ENSG00000034152Homo sapiens
 Map2k3ENSMUSG00000018932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*ENSGALG0000000437077
MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985* / P47809* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSGALG0000003217851
MAP2K2 / dual specificity mitogen-activated protein kinase kinase 2 / P36507* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein ...ENSGALG0000000126736
MAP2K5 / dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / mitogen-activated protein kinase kinase 5*ENSGALG0000000793036
MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSGALG0000000768736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042035 regulation of cytokine biosynthetic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / reaction
 ENSGALG00000013892 MAP3K5 / mitogen-activated protein kinase kinase kinase 5 / O35099* / Q99683*  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / reaction
 ENSGALG00000002283 MAPKAPK3 / Gallus gallus mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), mRNA. / Q16644* / Q3UMW7* / MAP kinase-activated protein kinase 3 * / mitogen-activated prot...  / reaction
 ENSGALG00000000883 MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137* / P49138* / MAP kinase-activated protein kinase 2 *  / reaction
 ENSGALG00000004743 MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41* / O54992* / Gm42878* / MAP kinase-activated protein kinase 5 *  / reaction
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / reaction






 

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