ENSG00000034152


Homo sapiens

Features
Gene ID: ENSG00000034152
  
Biological name :MAP2K3
  
Synonyms : MAP2K3 / mitogen-activated protein kinase kinase 3 / P46734
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p11.2
Gene start: 21284672
Gene end: 21315240
  
Corresponding Affymetrix probe sets: 207667_s_at (Human Genome U133 Plus 2.0 Array)   215498_s_at (Human Genome U133 Plus 2.0 Array)   215499_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464043
Ensembl peptide - ENSP00000463417
Ensembl peptide - ENSP00000478619
Ensembl peptide - ENSP00000486923
Ensembl peptide - ENSP00000319139
Ensembl peptide - ENSP00000345083
Ensembl peptide - ENSP00000355081
Ensembl peptide - ENSP00000378869
Ensembl peptide - ENSP00000431203
Ensembl peptide - ENSP00000434068
Ensembl peptide - ENSP00000462178
Ensembl peptide - ENSP00000463202
NCBI entrez gene - 5606     See in Manteia.
OMIM - 602315
RefSeq - XM_017024859
RefSeq - NM_001316332
RefSeq - NM_002756
RefSeq - NM_145109
RefSeq - XM_005256723
RefSeq - XM_011523958
RefSeq - XM_011523959
RefSeq - XM_017024857
RefSeq - XM_017024858
RefSeq Peptide - NP_002747
RefSeq Peptide - NP_659731
RefSeq Peptide - NP_001303261
swissprot - E9PRZ0
swissprot - J3KRV4
swissprot - J3QL77
swissprot - J3QR49
swissprot - Q6FI23
swissprot - X6RB39
swissprot - E9PMA8
swissprot - P46734
Ensembl - ENSG00000034152
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K3ENSGALG00000041285Gallus gallus
 Map2k3ENSMUSG00000018932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6ENSG0000010898477
MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4ENSG0000006555951
MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7ENSG0000007698440
MAP2K5 / Q13163 / mitogen-activated protein kinase kinase 5ENSG0000013776436
MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1ENSG0000016903236
MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2ENSG0000012693435
AC011005.1ENSG0000023062633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0035897 proteolysis in other organism TAS
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0038066 p38MAPK cascade IMP
 biological_processGO:0042035 regulation of cytokine biosynthetic process IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000114738 Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3  / reaction
 ENSG00000197442 MAP3K5 / Q99683 / mitogen-activated protein kinase kinase kinase 5  / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction






 

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