ENSG00000185386


Homo sapiens

Features
Gene ID: ENSG00000185386
  
Biological name :MAPK11
  
Synonyms : MAPK11 / mitogen-activated protein kinase 11 / Q15759
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.33
Gene start: 50263713
Gene end: 50270767
  
Corresponding Affymetrix probe sets: 206040_s_at (Human Genome U133 Plus 2.0 Array)   211499_s_at (Human Genome U133 Plus 2.0 Array)   211500_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333685
Ensembl peptide - ENSP00000379113
Ensembl peptide - ENSP00000409136
NCBI entrez gene - 5600     See in Manteia.
OMIM - 602898
RefSeq - XM_011530706
RefSeq - NM_002751
RefSeq Peptide - NP_002742
swissprot - Q15759
swissprot - F8WDP4
Ensembl - ENSG00000185386
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk11ENSDARG00000045836Danio rerio
 MAPK11ENSGALG00000040023Gallus gallus
 Mapk11ENSMUSG00000053137Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK14 / Q16539 / mitogen-activated protein kinase 14ENSG0000011206271
MAPK12 / P53778 / mitogen-activated protein kinase 12ENSG0000018813062
MAPK13 / O15264 / mitogen-activated protein kinase 13ENSG0000015671159
MAPK10 / P53779 / mitogen-activated protein kinase 10ENSG0000010933949
MAPK8 / P45983 / mitogen-activated protein kinase 8ENSG0000010764349
MAPK9 / P45984 / mitogen-activated protein kinase 9ENSG0000005074848


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:2001184 positive regulation of interleukin-12 secretion IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNA
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / complex / reaction
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex / reaction
 ENSG00000088247 KHSRP / Q92945 / KH-type splicing regulatory protein  / reaction
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / reaction / complex
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / complex / reaction
 ENSG00000008294 SPAG9 / O60271 / sperm associated antigen 9  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000140299 BNIP2 / Q12982 / BCL2 interacting protein 2  / reaction / complex
 ENSG00000068305 MEF2A / Q02078 / myocyte enhancer factor 2A  / reaction / complex
 ENSG00000115966 ATF2 / P15336 / activating transcription factor 2  / reaction
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000071564 TCF3 / P15923 / transcription factor 3  / reaction
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000114738 Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3  / reaction / complex
 ENSG00000100784 O75582 / RPS6KA5 / ribosomal protein S6 kinase A5  / reaction
 ENSG00000081189 MEF2C / Q06413 / myocyte enhancer factor 2C  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / complex






 

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