ENSG00000008294


Homo sapiens

Features
Gene ID: ENSG00000008294
  
Biological name :SPAG9
  
Synonyms : O60271 / SPAG9 / sperm associated antigen 9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.33
Gene start: 50962174
Gene end: 51120865
  
Corresponding Affymetrix probe sets: 1554543_at (Human Genome U133 Plus 2.0 Array)   206748_s_at (Human Genome U133 Plus 2.0 Array)   212468_at (Human Genome U133 Plus 2.0 Array)   212470_at (Human Genome U133 Plus 2.0 Array)   225339_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429343
Ensembl peptide - ENSP00000426900
Ensembl peptide - ENSP00000430205
Ensembl peptide - ENSP00000484908
Ensembl peptide - ENSP00000262013
Ensembl peptide - ENSP00000349636
Ensembl peptide - ENSP00000423165
Ensembl peptide - ENSP00000423346
Ensembl peptide - ENSP00000426061
NCBI entrez gene - 9043     See in Manteia.
OMIM - 605430
RefSeq - XM_017025285
RefSeq - NM_001130527
RefSeq - NM_001130528
RefSeq - NM_001251971
RefSeq - NM_003971
RefSeq - XM_005257768
RefSeq - XM_005257771
RefSeq - XM_005257774
RefSeq - XM_017025283
RefSeq - XM_017025284
RefSeq Peptide - NP_001123999
RefSeq Peptide - NP_001238900
RefSeq Peptide - NP_003962
RefSeq Peptide - NP_001124000
swissprot - H0YBS5
swissprot - O60271
swissprot - A0A087X2D8
swissprot - D6RHI8
swissprot - H0Y981
swissprot - H0YBE9
Ensembl - ENSG00000008294
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPAG9 (1 of many)ENSDARG00000078142Danio rerio
 spag9aENSDARG00000074531Danio rerio
 SPAG9ENSGALG00000034001Gallus gallus
 Spag9ENSMUSG00000020859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UPT6 / MAPK8IP3 / mitogen-activated protein kinase 8 interacting protein 3ENSG0000013883458
Q96PE2 / ARHGEF17 / Rho guanine nucleotide exchange factor 17ENSG0000011023723
Q9HCE6 / ARHGEF10L / Rho guanine nucleotide exchange factor 10 likeENSG0000007496414
O15013 / ARHGEF10 / Rho guanine nucleotide exchange factor 10ENSG0000010472814


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019143  JNK/Rab-associated protein-1, N-terminal
 IPR027267  AH/BAR domain superfamily
 IPR032486  JNK-interacting protein, leucine zipper II
 IPR034743  RH1 domain
 IPR034744  RH2 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity IBA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008432 JUN kinase binding IBA
 molecular_functionGO:0019894 kinesin binding IBA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IBA
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188130 MAPK12 / P53778 / mitogen-activated protein kinase 12  / complex / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction / complex
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / complex / reaction
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / complex / reaction
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex / reaction
 ENSG00000140299 BNIP2 / Q12982 / BCL2 interacting protein 2  / complex / reaction
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / reaction / complex
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / reaction / complex
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex






 

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