ENSG00000170558


Homo sapiens

Features
Gene ID: ENSG00000170558
  
Biological name :CDH2
  
Synonyms : cadherin 2 / CDH2 / P19022
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q12.1
Gene start: 27950966
Gene end: 28177446
  
Corresponding Affymetrix probe sets: 203440_at (Human Genome U133 Plus 2.0 Array)   203441_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000269141
Ensembl peptide - ENSP00000414269
Ensembl peptide - ENSP00000412120
Ensembl peptide - ENSP00000411360
Ensembl peptide - ENSP00000382312
NCBI entrez gene - 1000     See in Manteia.
OMIM - 114020
RefSeq - XM_017025514
RefSeq - NM_001308176
RefSeq - NM_001792
RefSeq - XM_011525788
RefSeq Peptide - NP_001783
RefSeq Peptide - NP_001295105
swissprot - C9J8J8
swissprot - P19022
swissprot - C9J126
swissprot - A0A024RC42
swissprot - C9JMH2
Ensembl - ENSG00000170558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh2ENSDARG00000018693Danio rerio
 CDH2ENSGALG00000015132Gallus gallus
 Cdh2ENSMUSG00000024304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDH4 / P55283 / cadherin 4ENSG0000017924266
CDH1 / P12830 / cadherin 1ENSG0000003906846
CDH3 / P22223 / cadherin 3ENSG0000006203840
CDH15 / P55291 / cadherin 15ENSG0000012991036
DSC1 / Q08554 / desmocollin 1ENSG0000013476532
CDH13 / P55290 / cadherin 13ENSG0000014094532
DSC3 / Q14574 / desmocollin 3ENSG0000013476231
DSC2 / Q02487 / desmocollin 2ENSG0000013475531
CDH26 / Q8IXH8 / cadherin 26ENSG0000012421527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR001849  Pleckstrin homology domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily
 IPR030051  N-cadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010001 glial cell differentiation ISS
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0034332 adherens junction organization TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin ISS
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0060019 radial glial cell differentiation IEA
 biological_processGO:0060563 neuroepithelial cell differentiation IEA
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097118 neuroligin clustering involved in postsynaptic membrane assembly IEA
 biological_processGO:0097150 neuronal stem cell population maintenance ISS
 biological_processGO:1902897 regulation of postsynaptic density protein 95 clustering IEA
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005916 fascia adherens IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0014704 intercalated disc ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016342 catenin complex IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding TAS
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045294 alpha-catenin binding IPI
 molecular_functionGO:0045295 gamma-catenin binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Adherens junctions interactions
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188130 MAPK12 / P53778 / mitogen-activated protein kinase 12  / reaction / complex
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction / complex
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / reaction / complex
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / complex
 ENSG00000008294 SPAG9 / O60271 / sperm associated antigen 9  / reaction / complex
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex
 ENSG00000140299 BNIP2 / Q12982 / BCL2 interacting protein 2  / complex / reaction
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / complex
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr