ENSMUSG00000024304


Mus musculus

Features
Gene ID: ENSMUSG00000024304
  
Biological name :Cdh2
  
Synonyms : Cadherin-2 / Cdh2 / P15116
  
Possible biological names infered from orthology : P19022
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 16588877
Gene end: 16809246
  
Corresponding Affymetrix probe sets: 10457644 (MoGene1.0st)   1418815_at (Mouse Genome 430 2.0 Array)   1439307_at (Mouse Genome 430 2.0 Array)   1449244_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111516
Ensembl peptide - ENSMUSP00000025166
NCBI entrez gene - 12558     See in Manteia.
MGI - MGI:88355
RefSeq - NM_007664
RefSeq - XM_006525553
RefSeq Peptide - NP_031690
swissprot - D3YYT0
swissprot - P15116
Ensembl - ENSMUSG00000024304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh2ENSDARG00000018693Danio rerio
 CDH2ENSGALG00000015132Gallus gallus
 CDH2ENSG00000170558Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdh4 / P39038 / Cadherin-4 / P55283*ENSMUSG0000000030566
Cdh1 / cadherin 1 / P12830*ENSMUSG0000000030346
Cdh3 / P10287 / Cadherin-3 / P22223*ENSMUSG0000006104841
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196236
Dsc2 / P55292 / Desmocollin-2 / Q02487*ENSMUSG0000002433133
Cdh13 / Q9WTR5 / Cadherin-13 / P55290*ENSMUSG0000003184132
Dsc3 / P55850 / Desmocollin-3 / Q14574*ENSMUSG0000005989831
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432229
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily
 IPR030051  N-cadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010001 glial cell differentiation IDA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0021537 telencephalon development IGI
 biological_processGO:0021987 cerebral cortex development IGI
 biological_processGO:0043410 positive regulation of MAPK cascade IGI
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin IDA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IGI
 biological_processGO:0048872 homeostasis of number of cells IGI
 biological_processGO:0051146 striated muscle cell differentiation IGI
 biological_processGO:0060019 radial glial cell differentiation IGI
 biological_processGO:0060563 neuroepithelial cell differentiation IGI
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IGI
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0097118 neuroligin clustering involved in postsynaptic membrane assembly IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IDA
 biological_processGO:1902897 regulation of postsynaptic density protein 95 clustering IMP
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005916 fascia adherens IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030425 dendrite IC
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0044853 plasma membrane raft IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048786 presynaptic active zone IC
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045294 alpha-catenin binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Adherens junctions interactions
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000778 abnormal tract 
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009685 abnormal spinal cord motor column morphology "any structural anomaly of the subclasses of motor neurons which are organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord; motor neurons within a single column send their axons to a common peripheral target" [PMID:8895454 "Tanabe Y, Jessell TM Diversity and pattern in the developing spinal cord. Science. 1996 Nov 15;274(5290):1115-23."]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / reaction / complex
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex / reaction






 

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