ENSMUSG00000031841


Mus musculus

Features
Gene ID: ENSMUSG00000031841
  
Biological name :Cdh13
  
Synonyms : Cadherin-13 / Cdh13 / Q9WTR5
  
Possible biological names infered from orthology : P55290
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 118283733
Gene end: 119324921
  
Corresponding Affymetrix probe sets: 10575844 (MoGene1.0st)   1423551_at (Mouse Genome 430 2.0 Array)   1431824_at (Mouse Genome 430 2.0 Array)   1434115_at (Mouse Genome 430 2.0 Array)   1454015_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113527
NCBI entrez gene - 12554     See in Manteia.
MGI - MGI:99551
RefSeq - XM_017312550
RefSeq - NM_019707
RefSeq - XM_006530628
RefSeq - XM_011248295
RefSeq Peptide - NP_062681
swissprot - Q9WTR5
Ensembl - ENSMUSG00000031841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh13ENSDARG00000014215Danio rerio
 CDH13ENSGALG00000005483Gallus gallus
 CDH13ENSG00000140945Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdh2 / P15116 / Cadherin-2 / P19022*ENSMUSG0000002430441
Cdh4 / P39038 / Cadherin-4 / P55283*ENSMUSG0000000030538
Cdh1 / cadherin 1 / P12830*ENSMUSG0000000030335
Cdh3 / P10287 / Cadherin-3 / P22223*ENSMUSG0000006104834
Dsc2 / P55292 / Desmocollin-2 / Q02487*ENSMUSG0000002433132
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196232
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432231
Dsc3 / P55850 / Desmocollin-3 / Q14574*ENSMUSG0000005989830
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915526


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR033216  Cadherin-13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISO
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051668 localization within membrane IEA
 biological_processGO:0055096 low-density lipoprotein particle mediated signaling IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0055100 adiponectin binding IDA
 molecular_functionGO:0071813 lipoprotein particle binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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