ENSMUSG00000061048


Mus musculus

Features
Gene ID: ENSMUSG00000061048
  
Biological name :Cdh3
  
Synonyms : Cadherin-3 / Cdh3 / P10287
  
Possible biological names infered from orthology : P22223
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 106510891
Gene end: 106557297
  
Corresponding Affymetrix probe sets: 10575034 (MoGene1.0st)   1426673_at (Mouse Genome 430 2.0 Array)   1441255_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079613
NCBI entrez gene - 12560     See in Manteia.
MGI - MGI:88356
RefSeq - NM_007665
RefSeq - NM_001037809
RefSeq Peptide - NP_001032898
RefSeq Peptide - NP_031691
swissprot - P10287
Ensembl - ENSMUSG00000061048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh1ENSDARG00000102750Danio rerio
 cdh28ENSDARG00000104332Danio rerio
 cdh30ENSDARG00000104440Danio rerio
 cdh31ENSDARG00000035796Danio rerio
 si:dkey-30c15.12ENSDARG00000058546Danio rerio
 CDH3ENSG00000062038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdh1 / cadherin 1 / P12830*ENSMUSG0000000030355
Cdh2 / P15116 / Cadherin-2 / P19022*ENSMUSG0000002430445
Cdh4 / P39038 / Cadherin-4 / P55283*ENSMUSG0000000030544
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196236
Dsc2 / P55292 / Desmocollin-2 / Q02487*ENSMUSG0000002433131
Dsc3 / P55850 / Desmocollin-3 / Q14574*ENSMUSG0000005989830
Cdh13 / Q9WTR5 / Cadherin-13 / P55290*ENSMUSG0000003184129
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432228
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IEA
 biological_processGO:0022405 hair cycle process IEA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0032773 positive regulation of monophenol monooxygenase activity IEA
 biological_processGO:0032912 negative regulation of transforming growth factor beta2 production IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048023 positive regulation of melanin biosynthetic process IEA
 biological_processGO:0051796 negative regulation of timing of catagen IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060901 regulation of hair cycle by canonical Wnt signaling pathway IEA
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1902910 positive regulation of melanosome transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001884 mammary alveolar hyperplasia 
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001885 mammary ductal hyperplasia 
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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