ENSDARG00000102750


Danio rerio

Features
Gene ID: ENSDARG00000102750
  
Biological name :cdh1
  
Synonyms : cadherin 1, type 1, E-cadherin (epithelial) / cdh1 / cdh30
  
Possible biological names infered from orthology : cadherin 1 / cadherin 3 / CDH3 / P10287 / P12830 / P22223
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 53059299
Gene end: 53117237
  
Corresponding Affymetrix probe sets: Dr.6007.1.S1_at (Zebrafish Array)   NM_131820_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000131992
Ensembl peptide - ENSDARP00000137597
Ensembl peptide - ENSDARP00000136579
Ensembl peptide - ENSDARP00000133971
NCBI entrez gene - 114424     See in Manteia.
RefSeq - NM_131820
RefSeq Peptide - NP_571895
swissprot - A0A0R4IJR6
swissprot - A0A0R4IFF8
swissprot - A0A0R4IQ86
swissprot - A0A0R4IL00
ZFIN ID - ZDB-GENE-010606-1
ZFIN ID - ZDB-GENE-110406-4
Ensembl - ENSDARG00000102750
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDH1ENSGALG00000000608Gallus gallus
 CDH1ENSG00000039068Homo sapiens
 CDH3ENSG00000062038Homo sapiens
 Cdh1ENSMUSG00000000303Mus musculus
 Cdh3ENSMUSG00000061048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdh30 / cadherin 30 / CDH1* / CDH3* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000010444065
cdh28 / cadherin 28 / CDH3* / CDH1* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000010433265
cdh31 / cadherin 31 / CDH1* / CDH3* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000003579657
cdh2 / cadherin 2, type 1, N-cadherin (neuronal) / P15116* / P19022* / cadherin 2*ENSDARG0000001869342
cdh4 / cadherin 4, type 1, R-cadherin (retinal) / P39038* / P55283* / cadherin 4*ENSDARG0000001500240
si:dkey-30c15.12 / CDH1* / CDH3* / P10287* / P12830* / P22223* / cadherin 3* / cadherin 1*ENSDARG0000005854635
cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*ENSDARG0000006819131
dsc2l / desmocollin 2 like / DSC3* / DSC1* / DSC2* / Q14574* / P55850* / Q02487* / Q08554* / P55292* / P55849* / desmocollin 3* / desmocollin 2* / desmocollin 1*ENSDARG0000003967729
cdh13 / cadherin 13, H-cadherin (heart) / P55290* / Q9WTR5* / cadherin 13*ENSDARG0000001421527
cdh26.2 / cadherin 26, tandem duplicate 2ENSDARG0000008764124
cdh27 / cadherin 27ENSDARG0000005509323
cdh26.1 / cadherin 26, tandem duplicate 1 / CDH26* / Q8IXH8* / P59862* / cadherin 26* / Cadherin-like protein 26 *ENSDARG0000007840421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0003370 cell-cell adhesion involved in mesendodermal cell migration IMP
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0034334 adherens junction maintenance IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IMP
 biological_processGO:0070586 cell-cell adhesion involved in gastrulation IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0016342 catenin complex IDA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Integrin cell surface interactions
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions
RHO GTPases activate IQGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000026 hatching gland hatching gland increased size , abnormal
hatching gland mislocalised , abnormal
Show

 ZFA:0000029 hindbrain hindbrain posterior region morphology , abnormal
Show

 ZFA:0000058 polster polster mislocalised , abnormal
polster morphology , abnormal
polster decreased length , abnormal
Show

 ZFA:0000075 spinal cord spinal cord anterior region morphology , abnormal
Show

 ZFA:0000077 tail bud tail bud decreased size , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
Show

 ZFA:0000135 notochord notochord kinked , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
Show

 ZFA:0000295 trigeminal ganglion trigeminal ganglion mislocalised laterally , abnormal
trigeminal ganglion neuron disorganized , abnormal
trigeminal ganglion neuron distributed , abnormal
Show

 ZFA:0000396 nervous system nervous system flattened , abnormal
Show

 ZFA:0000711 DEL DEL detached from EVL , abnormal
DEL position , abnormal
Show

 ZFA:0001065 lateral mesoderm lateral mesoderm mesodermal cell decreased speed , abnormal
lateral mesoderm mesodermal cell misrouted , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism necrotic , abnormal
whole organism quality , abnormal
Show

 ZFA:0001117 post-vent region post-vent region quality , abnormal
Show

 ZFA:0001135 neural tube neural tube cell mislocalised , abnormal
Show

 ZFA:0001378 axial hypoblast axial hypoblast filopodium decreased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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