ENSDARG00000018693


Danio rerio

Features
Gene ID: ENSDARG00000018693
  
Biological name :cdh2
  
Synonyms : cadherin 2, type 1, N-cadherin (neuronal) / cdh2
  
Possible biological names infered from orthology : cadherin 2 / P15116 / P19022
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 17581881
Gene end: 17819238
  
Corresponding Affymetrix probe sets: Dr.637.1.S1_at (Zebrafish Array)   Dr.637.1.S2_at (Zebrafish Array)   NM_131081_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003949
Ensembl peptide - ENSDARP00000149074
Ensembl peptide - ENSDARP00000156615
NCBI entrez gene - 30291     See in Manteia.
RefSeq - NM_131081
RefSeq Peptide - NP_571156
swissprot - G1K2E7
ZFIN ID - ZDB-GENE-990415-171
Ensembl - ENSDARG00000018693
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDH2ENSGALG00000015132Gallus gallus
 CDH2ENSG00000170558Homo sapiens
 Cdh2ENSMUSG00000024304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdh4 / cadherin 4, type 1, R-cadherin (retinal) / P39038* / P55283* / cadherin 4*ENSDARG0000001500260
cdh1 / cdh30 / cadherin 1, type 1, E-cadherin (epithelial) / CDH3* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000010275041
cdh31 / cadherin 31 / CDH1* / CDH3* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000003579638
cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*ENSDARG0000006819134
si:dkey-30c15.12 / CDH1* / CDH3* / P10287* / P12830* / P22223* / cadherin 3* / cadherin 1*ENSDARG0000005854632
cdh28 / cadherin 28 / CDH3* / CDH1* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000010433231
cdh13 / cadherin 13, H-cadherin (heart) / P55290* / Q9WTR5* / cadherin 13*ENSDARG0000001421530
cdh30 / cadherin 30 / CDH1* / CDH3* / P22223* / P10287* / P12830* / cadherin 3* / cadherin 1*ENSDARG0000010444030
dsc2l / desmocollin 2 like / DSC3* / DSC1* / DSC2* / Q14574* / P55850* / Q02487* / Q08554* / P55292* / P55849* / desmocollin 3* / desmocollin 2* / desmocollin 1*ENSDARG0000003967729
cdh26.2 / cadherin 26, tandem duplicate 2ENSDARG0000008764126
cdh27 / cadherin 27ENSDARG0000005509322
cdh26.1 / cadherin 26, tandem duplicate 1 / CDH26* / Q8IXH8* / P59862* / cadherin 26* / Cadherin-like protein 26 *ENSDARG0000007840421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily
 IPR030051  N-cadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Adherens junctions interactions
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
brain shape , abnormal
brain disorganized , abnormal
brain surface feature shape , abnormal
brain malformed , abnormal
brain cell spherical , abnormal
brain disoriented , abnormal
Show

 ZFA:0000019 epiphysis epiphysis split bilaterally , abnormal
epiphysis split , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer has fewer parts of type retinal ganglion cell , abnormal
retinal ganglion cell layer mislocalised , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
hindbrain radial glial cell morphology , abnormal
hindbrain radial glial cell mislocalised , abnormal
hindbrain disorganized , abnormal
hindbrain cell aggregated , abnormal
hindbrain cell loose , abnormal
hindbrain neuron disorganized , abnormal
hindbrain mitotic cell cycle decreased duration , abnormal
hindbrain morphology , abnormal
hindbrain dorsal region has extra parts of type neuron , abnormal
hindbrain motor neuron mislocalised dorsally , abnormal
hindbrain motor neuron mislocalised anteriorly , abnormal
hindbrain decreased thickness , abnormal
hindbrain surface feature shape , abnormal
Show

 ZFA:0000035 lens lens structure , abnormal
lens decreased size , abnormal
lens perforate , abnormal
lens disoriented , abnormal
lens mislocalised , abnormal
lens disorganized , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary absent , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer disorganized , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure defasciculated , abnormal
postoptic commissure commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000075 spinal cord spinal cord cell spherical , abnormal
spinal cord motor neuron axon guidance disrupted , abnormal
Show

 ZFA:0000077 tail bud tail bud morphology , abnormal
tail bud vacuolated , abnormal
tail bud paraxial mesoderm disorganized , abnormal
tail bud apoptotic , abnormal
tail bud increased width , abnormal
tail bud adherens junction morphology , abnormal
Show

 ZFA:0000092 axis axis melanoblast mislocalised medially , abnormal
axis condensed , abnormal
axis neural crest cell mislocalised medially , abnormal
Show

 ZFA:0000102 dorsal fin fold dorsal fin fold posterior side decreased size , abnormal
dorsal fin fold posterior side split medially , abnormal
Show

 ZFA:0000107 eye eye morphology , abnormal
eye proliferative region increased size , abnormal
eye proliferative region mislocalised , abnormal
eye fused with brain , abnormal
eye quality , abnormal
eye decreased size , abnormal
eye shape , abnormal
Show

 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle malformed , abnormal
fourth ventricle increased size , abnormal
fourth ventricle cell mislocalised , abnormal
fourth ventricle composition , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer has fewer parts of type neuroblast (sensu Vertebrata) , abnormal
Show

 ZFA:0000128 midbrain midbrain disorganized , abnormal
midbrain fourth ventricle mislocalised anteriorly , abnormal
midbrain quality , abnormal
midbrain cell loose , abnormal
midbrain dorsal region has extra parts of type neuron , abnormal
Show

 ZFA:0000132 neural plate neural plate increased width , abnormal
Show

 ZFA:0000133 neural rod neural rod shape , abnormal
neural rod neuroepithelial cell disorganized , abnormal
neural rod increased width , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud cartilage element absent , abnormal
pectoral fin bud cartilage element disorganized , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium poorly differentiated , abnormal
retinal pigmented epithelium position , abnormal
Show

 ZFA:0000152 retina retina quality , abnormal
retina neuron migration decreased occurrence , abnormal
retina sensory epithelium regeneration decreased occurrence , abnormal
retina disorganized , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
somite condensed , abnormal
somite quality , abnormal
somite fused with somite , abnormal
somite morphology , abnormal
somite disorganized , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm increased width , abnormal
paraxial mesoderm disorganized , abnormal
paraxial mesoderm mesodermal cell spherical , abnormal
Show

 ZFA:0000281 hair cell posterior macula hair cell posterior macula kinocilium decreased length , abnormal
hair cell posterior macula stereocilium bundle decreased length , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
semicircular canal morphology , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II defasciculated , abnormal
cranial nerve II decreased thickness , abnormal
cranial nerve II commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature quality , abnormal
Show

 ZFA:0000588 statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion decreased size , abnormal
Show

 ZFA:0000640 cornea cornea structure , abnormal
cornea anatomical surface structure , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula kinocilium decreased length , abnormal
Show

 ZFA:0000778 spinal cord interneuron spinal cord interneuron disorganized , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
posterior lateral line neuromast far from posterior lateral line neuromast , abnormal
Show

 ZFA:0001071 presumptive neural retina presumptive neural retina adherens junction detached from presumptive retinal pigmented epithelium , abnormal
Show

 ZFA:0001094 whole organism whole organism bent , abnormal
whole organism morphology , abnormal
whole organism has extra parts of type post-vent region , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism shape , abnormal
whole organism curved ventral , abnormal
whole organism organismal quality , abnormal
whole organism photoreceptor outer segment decreased length , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure defasciculated , abnormal
anterior commissure commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head surface feature shape , abnormal
Show

 ZFA:0001115 trunk trunk somite morphology , abnormal
trunk decreased thickness , abnormal
trunk bent , abnormal
trunk increased width , abnormal
trunk glial cell projection truncated , abnormal
trunk glial cell projection disorganized , abnormal
trunk glial cell projection kinked , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region vacuolated , abnormal
post-vent region clavate , abnormal
post-vent region somite morphology , abnormal
post-vent region curved dorsal , abnormal
post-vent region deformed , abnormal
post-vent region quality , abnormal
post-vent region morphology , abnormal
post-vent region truncated , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm malformed , abnormal
Show

 ZFA:0001135 neural tube neural tube cilium decreased length , abnormal
neural tube morphology , abnormal
neural tube cell increased amount , abnormal
Show

 ZFA:0001143 tooth 4V tooth 4V odontogenesis delayed , abnormal
Show

 ZFA:0001145 tooth 3V tooth 3V absent , abnormal
Show

 ZFA:0001202 optic cup optic cup neuron decreased amount , abnormal
Show

 ZFA:0001204 axial mesoderm axial mesoderm mesodermal cell mislocalised , abnormal
Show

 ZFA:0001261 ventricular system ventricular system composition , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer patchy , abnormal
retinal inner plexiform layer structure , abnormal
Show

 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer patchy , abnormal
retinal outer plexiform layer structure , abnormal
Show

 ZFA:0001357 alar plate midbrain region alar plate midbrain region separated from basal plate midbrain region , abnormal
Show

 ZFA:0001360 parapineal organ parapineal organ determination of left/right asymmetry in nervous system process quality , abnormal
Show

 ZFA:0001462 somite border somite border amorphous , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer has extra parts of type neuroblast (sensu Vertebrata) , abnormal
Show

 ZFA:0001683 corneal epithelium corneal epithelium saccular , abnormal
corneal epithelium desmosome decreased amount , abnormal
Show

 ZFA:0001685 corneal stroma corneal stroma disorganized , abnormal
Show

 ZFA:0001717 pillar of the semicircular canal pillar of the semicircular canal structure , abnormal
Show

 ZFA:0005209 hindbrain interneuron hindbrain interneuron irregular spatial pattern , abnormal
hindbrain interneuron disorganized , abnormal
hindbrain interneuron mislocalised , abnormal
Show

 ZFA:0005731 branchiomotor neuron branchiomotor neuron decreased cellular motility , abnormal
branchiomotor neuron neuron migration decreased velocity , abnormal
branchiomotor neuron detached from medial longitudinal fasciculus , abnormal
Show

 ZFA:0007023 posterior neural keel posterior neural keel increased width , abnormal
Show

 ZFA:0007024 anterior neural keel anterior neural keel flat , abnormal
anterior neural keel increased width , abnormal
Show

 ZFA:0007029 hindbrain neural keel hindbrain neural keel umbonate , abnormal
hindbrain neural keel shape , abnormal
Show

 ZFA:0007037 posterior neural tube posterior neural tube T-shaped , abnormal
Show

 ZFA:0007043 hindbrain neural tube hindbrain neural tube neuroepithelial cell morphology , abnormal
hindbrain neural tube increased distribution , abnormal
Show

 ZFA:0009000 cell cell filopodium present , abnormal
Show

 ZFA:0009063 peripheral neuron peripheral neuron quality , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell myofibril bent , abnormal
slow muscle cell myofibril elongated , abnormal
Show

 ZFA:0009138 mesodermal cell mesodermal cell mislocalised , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron irregular spatial pattern , abnormal
Mauthner neuron mislocalised , abnormal
Mauthner neuron displaced to rhombomere posterior region, abnormal
Show

 ZFA:0009264 corneal epithelial cell corneal epithelial cell cellular adhesivity corneal epithelial cell , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell apical-basal polarity , abnormal
neuroepithelial cell displaced to fourth ventricle , abnormal
neuroepithelial cell morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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