ENSGALG00000015132


Gallus gallus

Features
Gene ID: ENSGALG00000015132
  
Biological name :CDH2
  
Synonyms : Cadherin-2 / CDH2 / P10288
  
Possible biological names infered from orthology : P15116 / P19022
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 105084273
Gene end: 105197912
  
Corresponding Affymetrix probe sets: Gga.1917.1.S1_at (Chicken Array)   GgaAffx.21844.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024371
NCBI entrez gene - 414745     See in Manteia.
RefSeq - NM_001001615
RefSeq Peptide - NP_001001615
swissprot - P10288
Ensembl - ENSGALG00000015132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh2ENSDARG00000018693Danio rerio
 CDH2ENSG00000170558Homo sapiens
 Cdh2ENSMUSG00000024304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDH4 / cadherin-4 precursor / P39038* / P55283* / cadherin 4*ENSGALG0000000510264
CDH1 / cadherin 1 / P12830*ENSGALG0000000060844
CDH15 / cadherin 15 / P33146* / P55291*ENSGALG0000003004038
CDH13 / P33150 / Cadherin-13 / P55290* / Q9WTR5*ENSGALG0000000548331
DSC2* / DSC3* / DSC1* / Q14574* / P55850* / Q02487* / Q08554* / P55292* / P55849* / desmocollin 3* / desmocollin 2* / desmocollin 1*ENSGALG0000001514029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily
 IPR030051  N-cadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation TAS
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0036032 neural crest cell delamination IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin IMP
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0060019 radial glial cell differentiation IEA
 biological_processGO:0060173 limb development TAS
 biological_processGO:0060563 neuroepithelial cell differentiation IEA
 biological_processGO:0061561 trigeminal ganglion formation IMP
 biological_processGO:0061563 trigeminal ganglion structural organization IMP
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097118 neuroligin clustering involved in postsynaptic membrane assembly IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IMP
 biological_processGO:0098743 cell aggregation IMP
 biological_processGO:1902897 regulation of postsynaptic density protein 95 clustering IEA
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005916 fascia adherens IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0044853 plasma membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045294 alpha-catenin binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IPI
 molecular_functionGO:0045296 cadherin binding IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050840 extracellular matrix binding TAS


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Adherens junctions interactions
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003875 ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSGALG00000019384 MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*  / complex
 ENSGALG00000015152 BOC / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / reaction / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / complex
 ENSGALG00000015132 CDH2 / P10288 / Cadherin-2 / P15116* / P19022*  / complex
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex
 ENSGALG00000030040 CDH15 / cadherin 15 / P33146* / P55291*  / complex
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSGALG00000035419 CDON / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / reaction / complex






 

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