ENSGALG00000000608


Gallus gallus

Features
Gene ID: ENSGALG00000000608
  
Biological name :CDH1
  
Synonyms : cadherin 1 / CDH1
  
Possible biological names infered from orthology : P12830
  
Species: Gallus gallus
  
Chr. number: 11
Strand: 1
Band:
Gene start: 19110019
Gene end: 19123142
  
Corresponding Affymetrix probe sets: Gga.2982.1.S1_at (Chicken Array)   Gga.728.1.S1_a_at (Chicken Array)   Gga.728.2.A1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047930
Ensembl peptide - ENSGALP00000000855
NCBI entrez gene - 414845     See in Manteia.
NCBI entrez gene - 415860     See in Manteia.
RefSeq - NM_001039258
RefSeq - XM_003641956
RefSeq - XM_015292581
RefSeq Peptide - NP_001034347
swissprot - E1C6M9
swissprot - A0A1D5P5G2
Ensembl - ENSGALG00000000608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh1ENSDARG00000102750Danio rerio
 cdh28ENSDARG00000104332Danio rerio
 cdh30ENSDARG00000104440Danio rerio
 cdh31ENSDARG00000035796Danio rerio
 si:dkey-30c15.12ENSDARG00000058546Danio rerio
 CDH1ENSG00000039068Homo sapiens
 Cdh1ENSMUSG00000000303Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDH2 / P10288 / Cadherin-2 / P15116* / P19022*ENSGALG0000001513245
CDH4 / cadherin-4 precursor / P39038* / P55283* / cadherin 4*ENSGALG0000000510243
CDH15 / cadherin 15 / P33146* / P55291*ENSGALG0000003004037
CDH13 / P33150 / Cadherin-13 / P55290* / Q9WTR5*ENSGALG0000000548329
DSC2* / DSC3* / DSC1* / Q14574* / P55850* / Q02487* / Q08554* / P55292* / P55849* / desmocollin 3* / desmocollin 2* / desmocollin 1*ENSGALG0000001514028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071681 cellular response to indole-3-methanol IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0016600 flotillin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0043296 apical junction complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000608 CDH1 / cadherin 1 / P12830*  / complex
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / complex
 ENSGALG00000004212 ADAM10 / ADAM metallopeptidase domain 10 / O14672* / O35598* / Disintegrin and metalloproteinase domain-containing protein 10 *  / reaction
 ENSGALG00000006992 MMP9 / matrix metalloproteinase-9 precursor / P14780* / P41245* / matrix metallopeptidase 9* / Matrix metalloproteinase-9 *  / reaction
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction






 

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