ENSMUSG00000000303


Mus musculus

Features
Gene ID: ENSMUSG00000000303
  
Biological name :Cdh1
  
Synonyms : cadherin 1 / Cdh1
  
Possible biological names infered from orthology : P12830
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 106603351
Gene end: 106670246
  
Corresponding Affymetrix probe sets: 10575052 (MoGene1.0st)   1448261_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132112
Ensembl peptide - ENSMUSP00000000312
NCBI entrez gene - 12550     See in Manteia.
MGI - MGI:88354
RefSeq - NM_009864
RefSeq Peptide - NP_033994
swissprot - A0A0R4IZW5
Ensembl - ENSMUSG00000000303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh1ENSDARG00000102750Danio rerio
 cdh28ENSDARG00000104332Danio rerio
 cdh30ENSDARG00000104440Danio rerio
 cdh31ENSDARG00000035796Danio rerio
 si:dkey-30c15.12ENSDARG00000058546Danio rerio
 CDH1ENSGALG00000000608Gallus gallus
 CDH1ENSG00000039068Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdh3 / P10287 / Cadherin-3 / P22223*ENSMUSG0000006104852
Cdh2 / P15116 / Cadherin-2 / P19022*ENSMUSG0000002430447
Cdh4 / P39038 / Cadherin-4 / P55283*ENSMUSG0000000030545
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196235
Dsc2 / P55292 / Desmocollin-2 / Q02487*ENSMUSG0000002433131
Dsc3 / P55850 / Desmocollin-3 / Q14574*ENSMUSG0000005989830
Cdh13 / Q9WTR5 / Cadherin-13 / P55290*ENSMUSG0000003184129
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432228
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071681 cellular response to indole-3-methanol IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0016600 flotillin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0043296 apical junction complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Integrin cell surface interactions
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions
RHO GTPases activate IQGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0001272 increased metastatic potential 
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Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001711 abnormal placenta 
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1Jjon/Cdh1+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002013 pilomatriculoma "hair follicle tumor" [J:51296]
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Allelic Composition: Cdh1tm1Jjon/Cdh1+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Phb2tm1Katz/Phb2+
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh1tm1Jjon/Cdh1+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1.1Mpst/Cdh1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdh1tm1Cbm/Cdh1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdh1tm2.1Mpst/Cdh1tm2.1Mpst
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Cdh1tm1Kem/Cdh1tm1Kem
Genetic Background: involves: 129S2/SvPas

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rak/Apc+,Cdh1tm1Cbm/Cdh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdh1tm1Cbm/Cdh1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm1Jjon/Cdh1+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdh1tm3.1Mpst/Cdh1tm3.1Mpst
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008010 gastric adenocarcinoma "malignant neoplasm of epithelial cells in the stomach" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdh1tm2Kem/Cdh1tm2Kem,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0009311 duodenum adenocarcinoma "malignant neoplasm of epithelial cells in the duodenum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm2Kem/Cdh1+,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm1Cbm/Cdh1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0010038 abnormal placenta physiology "any functional anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1Jjon/Cdh1tm1Jjon,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdh1tm1Jjon/Cdh1+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Rak/Apc+,Cdh1tm1Cbm/Cdh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Phb2tm1Katz/Phb2+
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

Allelic Composition: Cdh1tm3.2Kem/Cdh1tm3.2Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdh1tm1Cbm/Cdh1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdh1tm2Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Bicc1jcpk-67Gso/Bicc1jcpk-67Gso,T(2;10)67Gso/T(2;10)67Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0012102 absent trophectoderm "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdh1tm2.1Mpst/Cdh1tm2.1Mpst
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0012111 failure of morula compaction "inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable" [MGI:anna]
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Allelic Composition: Cdh1tm1Cbm/Cdh1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0012119 increased trophectoderm apoptosis "increase in the number of trophectoderm cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Cdh1tm2.1Mpst/Cdh1tm2.1Mpst
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024947 Men1 / Menin / O88559 / O00255* / menin 1*  / complex / reaction
 ENSMUSG00000005947 Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*  / complex / reaction
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / complex / reaction
 ENSMUSG00000001281 Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*  / complex / reaction
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000017737 Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*  / reaction
 ENSMUSG00000028041 Adam15 / O88839 / Disintegrin and metalloproteinase domain-containing protein 15 / Q13444* / ADAM metallopeptidase domain 15*  / reaction
 ENSMUSG00000030713 Klk7 / Q91VE3 / Kallikrein-7 / P49862* / kallikrein related peptidase 7*  / reaction
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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