ENSMUSG00000059898


Mus musculus

Features
Gene ID: ENSMUSG00000059898
  
Biological name :Dsc3
  
Synonyms : Desmocollin-3 / Dsc3 / P55850
  
Possible biological names infered from orthology : Q14574
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A2
Gene start: 19960930
Gene end: 20002351
  
Corresponding Affymetrix probe sets: 10457669 (MoGene1.0st)   1427637_a_at (Mouse Genome 430 2.0 Array)   1434534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111514
Ensembl peptide - ENSMUSP00000153261
Ensembl peptide - ENSMUSP00000153279
NCBI entrez gene - 13507     See in Manteia.
MGI - MGI:1194993
RefSeq - XM_006525596
RefSeq - NM_001291809
RefSeq - NM_007882
RefSeq - XM_006525593
RefSeq Peptide - NP_031908
RefSeq Peptide - NP_001278738
swissprot - P55850
swissprot - A0A286YD62
Ensembl - ENSMUSG00000059898
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dsc2lENSDARG00000039677Danio rerio
 ENSGALG00000015140Gallus gallus
 DSC3ENSG00000134762Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dsc2 / P55292 / Desmocollin-2 / Q02487*ENSMUSG0000002433161
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432247
Cdh2 / P15116 / Cadherin-2 / P19022*ENSMUSG0000002430432
Cdh4 / P39038 / Cadherin-4 / P55283*ENSMUSG0000000030531
Cdh1 / cadherin 1 / P12830*ENSMUSG0000000030330
Cdh3 / P10287 / Cadherin-3 / P22223*ENSMUSG0000006104828
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196227
Cdh13 / Q9WTR5 / Cadherin-13 / P55290*ENSMUSG0000003184124
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR009122  Desmosomal cadherin
 IPR013783  Immunoglobulin-like fold
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0050821 protein stabilization ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030057 desmosome IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0045295 gamma-catenin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001217 absent epidermis "missing the epidermal cell layer in the skin" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Dsc3tm2Pko/Dsc3tm2Pko
Genetic Background: involves: 129S6/SvEvTac

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004241 acantholysis "separation of prickle cells of the spinous layer of the epidermis, resulting in atrophy of the prickle cell layer, as in conditions such as pemphigus vulgaris and Darier disease" [MESH:C17.800.865.070]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0030578 decreased keratinocyte adhesion "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
Show

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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