ENSMUSG00000024331


Mus musculus

Features
Gene ID: ENSMUSG00000024331
  
Biological name :Dsc2
  
Synonyms : Desmocollin-2 / Dsc2 / P55292
  
Possible biological names infered from orthology : Q02487
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A2
Gene start: 20030633
Gene end: 20059554
  
Corresponding Affymetrix probe sets: 10457686 (MoGene1.0st)   1421156_a_at (Mouse Genome 430 2.0 Array)   1426911_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042905
Ensembl peptide - ENSMUSP00000074702
Ensembl peptide - ENSMUSP00000116063
Ensembl peptide - ENSMUSP00000123010
NCBI entrez gene - 13506     See in Manteia.
MGI - MGI:103221
RefSeq - NM_001317363
RefSeq - NM_001317365
RefSeq - NM_013505
RefSeq Peptide - NP_001304294
RefSeq Peptide - NP_001304292
RefSeq Peptide - NP_038533
swissprot - P55292
swissprot - D6RDD6
swissprot - Q544V1
swissprot - F6RM34
Ensembl - ENSMUSG00000024331
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dsc2lENSDARG00000039677Danio rerio
 ENSGALG00000015140Gallus gallus
 DSC2ENSG00000134755Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dsc3 / P55850 / Desmocollin-3 / Q14574*ENSMUSG0000005989860
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432246
Cdh2 / P15116 / Cadherin-2 / P19022*ENSMUSG0000002430433
Cdh4 / P39038 / Cadherin-4 / P55283*ENSMUSG0000000030531
Cdh1 / cadherin 1 / P12830*ENSMUSG0000000030330
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196228
Cdh3 / P10287 / Cadherin-3 / P22223*ENSMUSG0000006104828
Cdh13 / Q9WTR5 / Cadherin-13 / P55290*ENSMUSG0000003184125
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR009122  Desmosomal cadherin
 IPR013783  Immunoglobulin-like fold
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0086042 cardiac muscle cell-cardiac muscle cell adhesion IEA
 biological_processGO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/Bay

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/Bay

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/Bay

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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