ENSMUSG00000000305


Mus musculus

Features
Gene ID: ENSMUSG00000000305
  
Biological name :Cdh4
  
Synonyms : Cadherin-4 / Cdh4 / P39038
  
Possible biological names infered from orthology : P55283
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 179442431
Gene end: 179899373
  
Corresponding Affymetrix probe sets: 10479274 (MoGene1.0st)   10479294 (MoGene1.0st)   1449422_at (Mouse Genome 430 2.0 Array)   1449637_at (Mouse Genome 430 2.0 Array)   1456397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000314
Ensembl peptide - ENSMUSP00000096594
Ensembl peptide - ENSMUSP00000104539
NCBI entrez gene - 12561     See in Manteia.
MGI - MGI:99218
RefSeq - XM_011239922
RefSeq - NM_001316723
RefSeq - NM_009867
RefSeq - XM_011239921
RefSeq Peptide - NP_033997
RefSeq Peptide - NP_001303652
swissprot - P39038
swissprot - Q80ZV4
swissprot - F6QV10
Ensembl - ENSMUSG00000000305
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh4ENSDARG00000015002Danio rerio
 CDH4ENSGALG00000005102Gallus gallus
 CDH4ENSG00000179242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdh2 / P15116 / Cadherin-2 / P19022*ENSMUSG0000002430465
Cdh1 / cadherin 1 / P12830*ENSMUSG0000000030343
Cdh3 / P10287 / Cadherin-3 / P22223*ENSMUSG0000006104840
Cdh15 / P33146 / Cadherin-15 / P55291*ENSMUSG0000003196236
Dsc3 / P55850 / Desmocollin-3 / Q14574*ENSMUSG0000005989831
Dsc2 / P55292 / Desmocollin-2 / Q02487*ENSMUSG0000002433131
Cdh13 / Q9WTR5 / Cadherin-13 / P55290*ENSMUSG0000003184130
Dsc1 / P55849 / Desmocollin-1 / Q08554*ENSMUSG0000004432227
Cdh26 / P59862 / Cadherin-like protein 26 / Q8IXH8* / cadherin 26*ENSMUSG0000003915524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0045773 positive regulation of axon extension IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Adherens junctions interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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