ENSMUSG00000031628


Mus musculus

Features
Gene ID: ENSMUSG00000031628
  
Biological name :Casp3
  
Synonyms : Casp3 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P70677
  
Possible biological names infered from orthology : caspase 3 / P42574
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.1
Gene start: 46617291
Gene end: 46639689
  
Corresponding Affymetrix probe sets: 10571696 (MoGene1.0st)   1426165_a_at (Mouse Genome 430 2.0 Array)   1430192_at (Mouse Genome 430 2.0 Array)   1449839_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091238
Ensembl peptide - ENSMUSP00000147700
Ensembl peptide - ENSMUSP00000147767
NCBI entrez gene - 12367     See in Manteia.
MGI - MGI:107739
RefSeq - XM_017312543
RefSeq - NM_001284409
RefSeq - NM_009810
RefSeq Peptide - NP_001271338
RefSeq Peptide - NP_033940
swissprot - P70677
swissprot - A0A1B0GRX1
Ensembl - ENSMUSG00000031628
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp3aENSDARG00000017905Danio rerio
 casp3bENSDARG00000055045Danio rerio
 CASP3ENSGALG00000010638Gallus gallus
 CASP3ENSG00000164305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*ENSMUSG0000002507653
Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*ENSMUSG0000002799738
Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*ENSMUSG0000002602934
Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*ENSMUSG0000002891434
Casp14 / O89094 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / P31...ENSMUSG0000000535527
Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*ENSMUSG0000002986327
Casp16-ps / caspase 16, apoptosis-related cysteine peptidase, pseudogeneENSMUSG0000006788215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress IDA
 biological_processGO:0009411 response to UV IGI
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010038 response to metal ion IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030218 erythrocyte differentiation IBA
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0032025 response to cobalt ion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034349 glial cell apoptotic process IMP
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
 biological_processGO:0045786 negative regulation of cell cycle IMP
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway ISO
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress NAS
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072734 cellular response to staurosporine ISO
 biological_processGO:0097194 execution phase of apoptosis ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity RCA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016005 phospholipase A2 activator activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process ISO
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Signaling by Hippo
NADE modulates death signalling
Activation of DNA fragmentation factor
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
via Dependence Receptors in the absence of ligand
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000032 cochlear degeneration "a retrogressive impairment of function or destruction of the part of the inner ear forms the anterior part of the labyrinth, is conical, and is concerned with hearing" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Casp3tm1Flv/Casp3+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Scribcrn2/Scribcrn2
Genetic Background: involves: A/J * FVB/N

 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak
Genetic Background: B6.129P2-Casp3tm1Mak

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Pde6brd1/Pde6brd1
Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Pde6brd1/Pde6brd1
Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak
Genetic Background: B6.129P2-Casp3tm1Mak

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/Casp9tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak
Genetic Background: B6.129P2-Casp3tm1Mak

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp3tm1Flv/Casp3+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0004528 fused outer hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak
Genetic Background: B6.129P2-Casp3tm1Mak

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3m1Bha/Casp3m1Bha
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Pde6brd1/Pde6brd1
Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J

 MP:0008517 thick retinal outer nuclear layer "increased thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Pde6brd1/Pde6brd1
Genetic Background: involves: 129S1 * C3H/FeJ * C57BL/6J

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak
Genetic Background: B6.129P2-Casp3tm1Mak

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0009581 decreased keratinocyte apoptosis "reduction in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0010259 anterior polar cataracts "a lens opacity, usually disk-shaped, that is limited to an area in the anterior pole of the lens capsular region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0030263 cranial bossing "abnormal prominence or protrusion of various bones of the skull; most often occurs in the frontal bones beneath the forehead" [https://en.wikipedia.org/wiki/Skull_bossing]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028914 Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*  / reaction
 ENSMUSG00000046432 Bex3 / Q9WTZ9 / Protein BEX3 / Q00994* / brain expressed X-linked 3*  / reaction
 ENSMUSG00000028974 Dffa / O54786 / DNA fragmentation factor subunit alpha / O00273*  / reaction
 ENSMUSG00000025876 Unc5a / Q8K1S4 / unc-5 netrin receptor A / Q6ZN44*  / reaction
 ENSMUSG00000031112 Stk26 / Q99JT2 / serine/threonine kinase 26 / Q9P289*  / reaction
 ENSMUSG00000001741 Il16 / O54824 / Pro-interleukin-16 Interleukin-16 / Q14005* / interleukin 16*  / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / reaction
 ENSMUSG00000029027 Dffb / O54788 / DNA fragmentation factor subunit beta / O76075*  / reaction
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000030498 Gas2 / P11862 / Mus musculus growth arrest specific 2 (Gas2), transcript variant 2, mRNA. / O43903* / growth arrest specific 2*  / reaction
 ENSMUSG00000030516 Tjp1 / P39447 / tight junction protein 1 / Q07157*  / reaction
 ENSMUSG00000029106 Add1 / Q9QYC0 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / P35611* / adducin 1*  / reaction
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / reaction
 ENSMUSG00000018209 Stk4 / Q9JI11 / serine/threonine kinase 4 / Q13043*  / reaction
 ENSMUSG00000069441 Dsg1a / Q61495 / Desmoglein-1-alpha / DSG1* / Q02413* / desmoglein 1*  / reaction
 ENSMUSG00000063410 Stk24 / Q99KH8 / serine/threonine kinase 24 / Q9Y6E0*  / reaction
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / reaction
 ENSMUSG00000061928 Dsg1b / Q7TSF1 / Desmoglein-1-beta / DSG1* / Q02413* / desmoglein 1*  / reaction
 ENSMUSG00000034774 Dsg1c / Q7TSF0 / Desmoglein-1-gamma / DSG1* / Q02413* / desmoglein 1*  / reaction
 ENSMUSG00000022329 Stk3 / Q9JI10 / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188* / serine/threonine kinase 3*  / reaction
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction
 ENSMUSG00000026413 Pkp1 / P97350 / Plakophilin-1 / Q13835*  / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction
 ENSMUSG00000054889 Dsp / E9Q557 / Desmoplakin / P15924*  / reaction
 ENSMUSG00000024812 Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / complex
 ENSMUSG00000022185 Acin1 / Q9JIX8 / apoptotic chromatin condensation inducer 1 / Q9UKV3*  / reaction
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / reaction
 ENSMUSG00000015994 Fnta / Q61239 / Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha / P49354* / farnesyltransferase, CAAX box, alpha*  / reaction
 ENSMUSG00000021067 1 / Sav1 / Q8VEB2 / Q9H4B6* / salvador family WW domain containing protein 1*  / reaction
 ENSMUSG00000044393 Dsg2 / O55111 / Desmoglein-2 / Q14126*  / reaction
 ENSMUSG00000018411 Mapt / P10637 / Microtubule-associated protein tau / P10636*  / reaction
 ENSMUSG00000026728 Vim / P20152 / vimentin / P08670*  / reaction
 ENSMUSG00000026879 Gsn / P13020 / gelsolin / P06396*  / reaction
 ENSMUSG00000021638 Ocln / Q61146 / occludin / Q16625*  / reaction
 ENSMUSG00000031377 Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000056632 Dsg3 / desmoglein 3 / P32926*  / reaction
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / reaction






 

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