ENSMUSG00000031377


Mus musculus

Features
Gene ID: ENSMUSG00000031377
  
Biological name :Bmx
  
Synonyms : Bmx / Cytoplasmic tyrosine-protein kinase BMX / P97504
  
Possible biological names infered from orthology : BMX non-receptor tyrosine kinase / P51813
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 164192842
Gene end: 164258193
  
Corresponding Affymetrix probe sets: 10607752 (MoGene1.0st)   1422084_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107882
Ensembl peptide - ENSMUSP00000107884
NCBI entrez gene - 12169     See in Manteia.
MGI - MGI:1101778
RefSeq - NM_009759
RefSeq Peptide - NP_033889
swissprot - B1AUL6
swissprot - B1AUL5
swissprot - P97504
Ensembl - ENSMUSG00000031377
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMXENSGALG00000016557Gallus gallus
 BMXENSG00000102010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126448
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039546
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921746
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489235
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012727
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315827
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684227
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659626
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231224
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028840  Cytoplasmic tyrosine-protein kinase BMX
 IPR035875  BMX, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001865 NK T cell differentiation IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046777 protein autophosphorylation ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032587 ruffle membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction
 ENSMUSG00000020375 Rufy1 / Q8BIJ7 / RUN and FYVE domain-containing protein 1 / Q96T51* / RUN and FYVE domain containing 1*  / reaction






 

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