ENSMUSG00000004933


Mus musculus

Features
Gene ID: ENSMUSG00000004933
  
Biological name :Matk
  
Synonyms : Matk / megakaryocyte-associated tyrosine kinase
  
Possible biological names infered from orthology : P42679
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81252935
Gene end: 81263365
  
Corresponding Affymetrix probe sets: 10365037 (MoGene1.0st)   1421739_a_at (Mouse Genome 430 2.0 Array)   1432329_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113221
Ensembl peptide - ENSMUSP00000113043
Ensembl peptide - ENSMUSP00000113576
Ensembl peptide - ENSMUSP00000122445
Ensembl peptide - ENSMUSP00000114233
Ensembl peptide - ENSMUSP00000113666
Ensembl peptide - ENSMUSP00000100965
NCBI entrez gene - 17179     See in Manteia.
MGI - MGI:99259
RefSeq - XM_011243377
RefSeq - NM_001285854
RefSeq - NM_001285855
RefSeq - NM_010768
RefSeq - XM_006513294
RefSeq - XM_006513295
RefSeq - XM_006513298
RefSeq - XM_006513299
RefSeq - XM_006513300
RefSeq - XM_011243376
RefSeq - NM_001285853
RefSeq Peptide - NP_001272782
RefSeq Peptide - NP_001272783
RefSeq Peptide - NP_001272784
RefSeq Peptide - NP_034898
swissprot - D6RGA0
swissprot - A0A0R4J1N6
swissprot - D3Z4T5
swissprot - D3YVQ8
swissprot - A0A0R4J1P8
Ensembl - ENSMUSG00000004933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 matkENSDARG00000074670Danio rerio
 MATKENSGALG00000000736Gallus gallus
 MATKENSG00000007264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231246
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684235
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659634
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315832
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012731
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921730
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039530
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489229
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126429
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035027  CSK-like, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Matktm1Suda/Matktm1Suda
Genetic Background: involves: C57BL/6 * CBA

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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