ENSMUSG00000026842


Mus musculus

Features
Gene ID: ENSMUSG00000026842
  
Biological name :Abl1
  
Synonyms : Abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00520
  
Possible biological names infered from orthology : ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 31688376
Gene end: 31804227
  
Corresponding Affymetrix probe sets: 10471201 (MoGene1.0st)   1423999_at (Mouse Genome 430 2.0 Array)   1441291_at (Mouse Genome 430 2.0 Array)   1444134_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117748
Ensembl peptide - ENSMUSP00000075167
Ensembl peptide - ENSMUSP00000141320
Ensembl peptide - ENSMUSP00000142297
Ensembl peptide - ENSMUSP00000142123
Ensembl peptide - ENSMUSP00000028190
NCBI entrez gene - 11350     See in Manteia.
MGI - MGI:87859
RefSeq - XM_006497621
RefSeq - NM_001112703
RefSeq - NM_001283045
RefSeq - NM_001283046
RefSeq - NM_001283047
RefSeq - NM_009594
RefSeq Peptide - NP_033724
RefSeq Peptide - NP_001106174
RefSeq Peptide - NP_001269974
RefSeq Peptide - NP_001269975
RefSeq Peptide - NP_001269976
swissprot - P00520
swissprot - A2AV23
swissprot - Q3SYK5
swissprot - A0A0A6YVY6
swissprot - A0A0A6YY65
swissprot - A0A0A6YXS9
Ensembl - ENSMUSG00000026842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abl1ENSDARG00000035187Danio rerio
 ABL1ENSGALG00000003875Gallus gallus
 ABL1ENSG00000097007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659654
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126418
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921717
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039516
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012716
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231216
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489216
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137715
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315815
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015015  F-actin binding
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR033221  Tyrosine-protein kinase ABL1/transforming protein Abl
 IPR035837  Tyrosine-protein kinase ABL, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0001922 B-1 B cell homeostasis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002322 B cell proliferation involved in immune response IMP
 biological_processGO:0002333 transitional one stage B cell differentiation IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006975 DNA damage induced protein phosphorylation ISO
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IGI
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021587 cerebellum morphogenesis IGI
 biological_processGO:0022408 negative regulation of cell-cell adhesion IGI
 biological_processGO:0030035 microspike assembly IDA
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0030182 neuron differentiation IGI
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0030516 regulation of axon extension ISO
 biological_processGO:0031113 regulation of microtubule polymerization ISO
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction ISO
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISO
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway ISO
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation ISO
 biological_processGO:0038189 neuropilin signaling pathway ISO
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042770 signal transduction in response to DNA damage ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043542 endothelial cell migration ISO
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045184 establishment of protein localization ISO
 biological_processGO:0045580 regulation of T cell differentiation IMP
 biological_processGO:0045930 negative regulation of mitotic cell cycle IGI
 biological_processGO:0045931 positive regulation of mitotic cell cycle IGI
 biological_processGO:0046632 alpha-beta T cell differentiation IGI
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048668 collateral sprouting IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050798 activated T cell proliferation IMP
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IGI
 biological_processGO:0051353 positive regulation of oxidoreductase activity ISO
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly ISO
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISO
 biological_processGO:0060020 Bergmann glial cell differentiation IGI
 biological_processGO:0060563 neuroepithelial cell differentiation IGI
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0072358 cardiovascular system development IGI
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0090135 actin filament branching IMP
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISO
 biological_processGO:1900042 positive regulation of interleukin-2 secretion IGI
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IGI
 biological_processGO:1900275 negative regulation of phospholipase C activity ISO
 biological_processGO:1901216 positive regulation of neuron death IMP
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IGI
 biological_processGO:1903053 regulation of extracellular matrix organization IGI
 biological_processGO:1904528 positive regulation of microtubule binding ISO
 biological_processGO:1904531 positive regulation of actin filament binding ISO
 biological_processGO:1905244 regulation of modification of synaptic structure IGI
 biological_processGO:1905555 positive regulation blood vessel branching IMP
 biological_processGO:1990051 activation of protein kinase C activity ISO
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization ISO
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IGI
 biological_processGO:2000772 regulation of cellular senescence IGI
 biological_processGO:2000773 negative regulation of cellular senescence IGI
 biological_processGO:2001020 regulation of response to DNA damage stimulus ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005080 protein kinase C binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0019905 syntaxin binding ISO
 molecular_functionGO:0030145 manganese ion binding ISO
 molecular_functionGO:0038191 neuropilin binding ISO
 molecular_functionGO:0042169 SH2 domain binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0051015 actin filament binding IDA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding ISO
 molecular_functionGO:0070064 proline-rich region binding ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
Role of ABL in ROBO-SLIT signaling
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: 129S/SvEv-Abl1tm1Mlg

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*I)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*IV)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*I)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*K290R)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

Allelic Composition: Abl1tm1.1Gcos/Abl1tm1.1Gcos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

Allelic Composition: Abl1tm1.1Goff/Abl1tm1.1Goff
Genetic Background: involves: C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: 129S/SvEv-Abl1tm1Mlg

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*K290R)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0002763 ectopic Bergmann glia cells "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:4978]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

Allelic Composition: Abl1tm1Goff/Abl1tm1Goff,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0004545 enlarged esophagus "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0006098 absent cerebellar lobules "missing lobes of the cerebellum" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0006321 increased myocardial fiber number "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*K290R)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

Allelic Composition: Abl1tm1.1Gcos/Abl1tm1.1Gcos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009216 abnormal peritoneum morphology "any structural abnormality of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009268 absent cerebellum fissure "absence of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009978 abnormal cerebellum white matter morphology 
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Tg(ACTB-Abl1*K290R)1Spg/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: 129S/SvEv-Abl1tm1Mlg

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Abl1tm1Goff/Abl1tm1Goff,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Abl1tm1Goff/Abl1tm1Goff
Genetic Background: involves: C57BL/6

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: B6.129-Abl1m1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011394 increased fetal cardiomyocyte proliferation "increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: B6.129-Abl1tm1Mlg

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0013551 decreased cerebellar granule cell precursor proliferation "reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [MGI:csmith]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / complex
 ENSMUSG00000022883 Robo1 / roundabout guidance receptor 1 / Q9Y6N7*  / complex / reaction
 ENSMUSG00000020859 Spag9 / Q58A65 / sperm associated antigen 9 / O60271*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000030166 Rad52 / P43352 / RAD52 homolog, DNA repair protein / P43351*  / reaction
 ENSMUSG00000025372 Baiap2 / Q8BKX1 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q9UQB8* / BAI1 associated protein 2*  / reaction
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / reaction
 ENSMUSG00000040957 Q9ESJ1 / Cables1 / CDK5 and ABL1 enzyme substrate 1 / Q8TDN4* / Cdk5 and Abl enzyme substrate 1*  / reaction / complex
 ENSMUSG00000024304 Cdh2 / P15116 / Cadherin-2 / P19022*  / complex
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex / reaction
 ENSMUSG00000031962 Cdh15 / P33146 / Cadherin-15 / P55291*  / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex
 ENSMUSG00000033022 Cdo1 / P60334 / Cysteine dioxygenase type 1 / Q16878*  / complex / reaction
 ENSMUSG00000038119 Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*  / complex
 ENSMUSG00000031558 Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*  / complex / reaction
 ENSMUSG00000063063 Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*  / complex
 ENSMUSG00000022610 Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*  / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / complex
 ENSMUSG00000022687 Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

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