ENSGALG00000003875


Gallus gallus

Features
Gene ID: ENSGALG00000003875
  
Biological name :ABL1
  
Synonyms : ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase
  
Possible biological names infered from orthology : c-abl oncogene 1, non-receptor tyrosine kinase / P00519 / P00520
  
Species: Gallus gallus
  
Chr. number: 17
Strand: 1
Band:
Gene start: 6472913
Gene end: 6500584
  
Corresponding Affymetrix probe sets: Gga.15131.1.S1_at (Chicken Array)   Gga.6257.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006154
NCBI entrez gene - 417181     See in Manteia.
RefSeq - XM_015279734
RefSeq - XM_015279735
swissprot - F1NCD9
Ensembl - ENSGALG00000003875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abl1ENSDARG00000035187Danio rerio
 ABL1ENSG00000097007Homo sapiens
 Abl1ENSMUSG00000026842Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABL2* / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSGALG0000003035754
BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *ENSGALG0000000495817
TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*ENSGALG0000001412416
CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*ENSGALG0000003127016
TXK / TXK tyrosine kinase / P42681* / P42682*ENSGALG0000001412716
ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSGALG0000000385716
MATK / megakaryocyte-associated tyrosine kinase / P42679*ENSGALG0000000073614
FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSGALG0000000834014
BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *ENSGALG0000001655714
FER / FER tyrosine kinase / P16591* / P70451* / Tyrosine-protein kinase Fer *ENSGALG000000002736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015015  F-actin binding
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR033221  Tyrosine-protein kinase ABL1/transforming protein Abl


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001922 B-1 B cell homeostasis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002322 B cell proliferation involved in immune response IEA
 biological_processGO:0002333 transitional one stage B cell differentiation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021587 cerebellum morphogenesis IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030035 microspike assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0031113 regulation of microtubule polymerization IEA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0038189 neuropilin signaling pathway IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045580 regulation of T cell differentiation IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0046632 alpha-beta T cell differentiation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048668 collateral sprouting IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050798 activated T cell proliferation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051353 positive regulation of oxidoreductase activity IEA
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060563 neuroepithelial cell differentiation IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072358 cardiovascular system development IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090135 actin filament branching IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1900042 positive regulation of interleukin-2 secretion IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1900275 negative regulation of phospholipase C activity IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IEA
 biological_processGO:1903053 regulation of extracellular matrix organization IEA
 biological_processGO:1904528 positive regulation of microtubule binding IEA
 biological_processGO:1904531 positive regulation of actin filament binding IEA
 biological_processGO:1905244 regulation of modification of synaptic structure IEA
 biological_processGO:1905555 positive regulation blood vessel branching IEA
 biological_processGO:1990051 activation of protein kinase C activity IEA
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000772 regulation of cellular senescence IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 biological_processGO:2001020 regulation of response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0038191 neuropilin binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA
 molecular_functionGO:0070064 proline-rich region binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
Role of ABL in ROBO-SLIT signaling
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex
 ENSGALG00000035419 CDON / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSGALG00000030040 CDH15 / cadherin 15 / P33146* / P55291*  / complex
 ENSGALG00000042538 BAIAP2 / BAI1 associated protein 2 / Q8BKX1* / Q9UQB8* / Brain-specific angiosis inhibitor 1-associated protein 2 *  / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction
 ENSGALG00000015152 BOC / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / complex
 ENSGALG00000015132 CDH2 / P10288 / Cadherin-2 / P15116* / P19022*  / complex
 ENSGALG00000039171 RAD52 / DNA repair protein RAD52 homolog isoform 2 / P43351* / P43352* / RAD52 homolog, DNA repair protein*  / reaction
 ENSGALG00000019384 MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*  / complex
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex






 

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