ENSGALG00000008340


Gallus gallus

Features
Gene ID: ENSGALG00000008340
  
Biological name :FES
  
Synonyms : FES / FES proto-oncogene, tyrosine kinase
  
Possible biological names infered from orthology : P07332 / P16879 / Tyrosine-protein kinase Fes/Fps
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 20121674
Gene end: 20126721
  
Corresponding Affymetrix probe sets: GgaAffx.5263.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058546
Ensembl peptide - ENSGALP00000013565
NCBI entrez gene - 429374     See in Manteia.
RefSeq - XM_015292163
RefSeq - XM_015292160
RefSeq - XM_015292161
RefSeq - XM_003641868
RefSeq - XM_015292158
RefSeq - XM_015292159
swissprot - F1NXT2
swissprot - A0A1D5PZX7
Ensembl - ENSGALG00000008340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fesENSDARG00000011449Danio rerio
 FESENSG00000182511Homo sapiens
 FesENSMUSG00000053158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FER / FER tyrosine kinase / P16591* / P70451* / Tyrosine-protein kinase Fer *ENSGALG0000000027332
TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*ENSGALG0000001412419
BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *ENSGALG0000000495819
ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSGALG0000000385719
ABL2* / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSGALG0000003035718
ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*ENSGALG0000000387518
BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *ENSGALG0000001655718
TXK / TXK tyrosine kinase / P42681* / P42682*ENSGALG0000001412717
CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*ENSGALG0000003127016
MATK / megakaryocyte-associated tyrosine kinase / P42679*ENSGALG0000000073616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:2000145 regulation of cell motility IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Sema3A PAK dependent Axon repulsion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000001264 PLXNA2 / plexin A2 / O75051* / P70207*  / complex
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex
 ENSGALG00000006097 PLXNA1 / plexin A1 / P70206* / Q9UIW2*  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex






 

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