ENSGALG00000011206


Gallus gallus

Features
Gene ID: ENSGALG00000011206
  
Biological name :KITLG
  
Synonyms : KITLG / Kit ligand Processed kit ligand / Q09108
  
Possible biological names infered from orthology : Kitl / KIT ligand / Kit ligand Soluble KIT ligand / P20826 / P21583
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 42981399
Gene end: 43032887
  
Corresponding Affymetrix probe sets: Gga.605.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018246
Ensembl peptide - ENSGALP00000041618
Ensembl peptide - ENSGALP00000042694
NCBI entrez gene - 396028     See in Manteia.
RefSeq - NM_001105315
RefSeq - NM_205130
RefSeq Peptide - NP_001098785
RefSeq Peptide - NP_990461
swissprot - Q009U4
swissprot - Q009U6
swissprot - Q09108
swissprot - R4GHR3
Ensembl - ENSGALG00000011206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KITLGENSG00000049130Homo sapiens
 KitlENSMUSG00000019966Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003452  Stem cell factor
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0002763 positive regulation of myeloid leukocyte differentiation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0033026 negative regulation of mast cell apoptotic process IEA
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045636 positive regulation of melanocyte differentiation IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0070668 positive regulation of mast cell proliferation IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:1902035 positive regulation of hematopoietic stem cell proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005173 stem cell factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008340 FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000006992 MMP9 / matrix metalloproteinase-9 precursor / P14780* / P41245* / matrix metallopeptidase 9* / Matrix metalloproteinase-9 *  / reaction
 ENSGALG00000014124 TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000014561 PTPN6 / tyrosine-protein phosphatase non-receptor type 6 / P29350* / P29351* / protein tyrosine phosphatase, non-receptor type 6*  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction / complex
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSGALG00000013100 GRB10 / growth factor receptor bound protein 10 / Q13322* / Q60760*  / reaction / complex
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex / reaction
 ENSGALG00000042418 CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1 / O14757* / O35280* / checkpoint kinase 1*  / complex / reaction






 

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