ENSMUSG00000019966


Mus musculus

Features
Gene ID: ENSMUSG00000019966
  
Biological name :Kitl
  
Synonyms : Kitl / Kit ligand Soluble KIT ligand / P20826
  
Possible biological names infered from orthology : KITLG / KIT ligand / P21583
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 100015630
Gene end: 100100416
  
Corresponding Affymetrix probe sets: 10366052 (MoGene1.0st)   1415854_at (Mouse Genome 430 2.0 Array)   1415855_at (Mouse Genome 430 2.0 Array)   1426152_a_at (Mouse Genome 430 2.0 Array)   1448117_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020129
Ensembl peptide - ENSMUSP00000100920
Ensembl peptide - ENSMUSP00000123360
Ensembl peptide - ENSMUSP00000151554
NCBI entrez gene - 17311     See in Manteia.
MGI - MGI:96974
RefSeq - XM_017313823
RefSeq - NM_013598
RefSeq - XM_006513314
RefSeq - XM_006513315
RefSeq Peptide - NP_001334085
RefSeq Peptide - NP_038626
swissprot - P20826
swissprot - Q8C9K1
swissprot - A0A1W2P773
Ensembl - ENSMUSG00000019966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KITLGENSGALG00000011206Gallus gallus
 KITLGENSG00000049130Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003452  Stem cell factor
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001755 neural crest cell migration IDA
 biological_processGO:0002687 positive regulation of leukocyte migration IDA
 biological_processGO:0002763 positive regulation of myeloid leukocyte differentiation IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007281 germ cell development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0033026 negative regulation of mast cell apoptotic process IDA
 biological_processGO:0035162 embryonic hemopoiesis ISO
 biological_processGO:0035234 ectopic germ cell programmed cell death IMP
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043406 positive regulation of MAP kinase activity IGI
 biological_processGO:0045636 positive regulation of melanocyte differentiation IDA
 biological_processGO:0045740 positive regulation of DNA replication ISO
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0070668 positive regulation of mast cell proliferation IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:1902035 positive regulation of hematopoietic stem cell proliferation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005173 stem cell factor receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-30R/Kitl+
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/Kitl+
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/KitlSl-2Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-20J/Kitl+
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

Allelic Composition: Kitltm2.1Pbes/Kitltm2.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Kitltm2.1Sjm/Kitltm2.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Fastm1.1Cgn
Genetic Background: involves: C57BL/6 * MRL

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: either: (involves: C57BL/6 * DBA/2J) or (involves: C3H * C57BL/6 * DBA/2J * WC)

Allelic Composition: KitlSl/Kitl+
Genetic Background: either: (involves: C3H * WC) or (involves: C3H * C57BL/6 * DBA/2J * WC)

Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: KitlSl/Kitl+,Tg(PGK1-KITLG*220)441Daw/0
Genetic Background: involves: C3H

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Brd/Bmp2tm1.1Mis,Gfi1tm1(cre)Gan/Gfi1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0000370 head blaze "the appearance of a stripe of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-18H/KitlSl-con
Genetic Background: Not Specified

Allelic Composition: Kitlsl-blz/Kitlsl-blz
Genetic Background: WSB/EiJ

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW/Kit+
Genetic Background: Not Specified

Allelic Composition: KitlSl-36H/KitlSl-36H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: KitlSl-37H/KitlSl-37H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: either: DBA/2J or (C57BL/6 x DBA/2)F1

Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-pan/Kitl+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-17H/Kitl+
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-17H/KitlSl-con
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: KitlSl-22J/Kitl+
Genetic Background: C57BL/6J-KitlSl-22J/GrsrJ

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

Allelic Composition: KitlSl-3R/Kitl+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-12R/Kitl+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-18H/KitlSl-con
Genetic Background: Not Specified

Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/KitlSl-2Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-3Neu/KitlSl-3Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-J/Kitl+
Genetic Background: C3HeB/FeHu-KitlSl-J

Allelic Composition: Kitlsl-du/Kitlsl-du
Genetic Background: C3H/HeJ-Kitlsl-du

Allelic Composition: Kitltm2.1Pbes/KitlSl
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6J * FVB/N

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: involves: DBA/2J

Allelic Composition: KitlSl-10H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-t/Kitl+
Genetic Background: B6.Cg-KitlSl-t

Allelic Composition: KitlSl-16J/Kitl+
Genetic Background: involves: 129 * Lipari

Allelic Composition: KitlSl-so/Kitl+
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-m/Kitl+
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-Clo/Kitl+
Genetic Background: Not Specified

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

Allelic Composition: KitlSl-26H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-27H/Kitl+
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-30H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Kitlsl-blz/Kitlsl-blz
Genetic Background: WSB/EiJ

Allelic Composition: KitlSl-34H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-17H/Kitl+
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-d/Kitl+,Ph/Ph+
Genetic Background: involves: C57BL/Gr * DBA/2J

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

Allelic Composition: KitlSl-20J/Kitl+
Genetic Background: C57BL/6J-KitlSl-20J/J

Allelic Composition: KitlSl-17H/Kitl+
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: KitlSl-22J/Kitl+
Genetic Background: C57BL/6J-KitlSl-22J/GrsrJ

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-J/Kitl+
Genetic Background: C3HeB/FeHu-KitlSl-J

Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Allelic Composition: KitlM1Bao/Kitl+
Genetic Background: involves: C57BL/6J

Allelic Composition: KitlSl-13H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-15H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-21H/Kitl+
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-31H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Kitlsl-blz/Kitlsl-blz
Genetic Background: WSB/EiJ

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0000472 abnormal stomach squamous epithelium morphology "malformation of the scaly epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Nr3c1tm1.1Mvc/Nr3c1+,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic Background: BKa.129S6-Kitltm1.1Sjm

Allelic Composition: Kitltm2.1Sjm/Kitltm2.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: KitlSl-20J/Kitl+
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kitltm2.1Sjm/Kitltm2.2Sjm,Tg(Tek-cre)12Flv/0
Genetic Background: involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: CrygdAey4/Crygd+
Genetic Background: C3HeB/FeJ-CrygdAey4

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0001189 absent skin pigmentation "lack of pigmentation of the skin" [J:53370]
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Allelic Composition: CrygdAey4/Crygd+
Genetic Background: C3HeB/FeJ-CrygdAey4

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: KitlSl-d/Kitl+
Genetic Background: either: DBA/2J or (C57BL/6 x DBA/2)F1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: either: (involves: C57BL/6 * DBA/2J) or (involves: C3H * C57BL/6 * DBA/2J * WC)

Allelic Composition: KitlSl/Kitl+
Genetic Background: either: (involves: C3H * WC) or (involves: C3H * C57BL/6 * DBA/2J * WC)

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-J/KitlSl-J
Genetic Background: C3HeB/FeHu-KitlSl-J

Allelic Composition: Kitlsl-du/Kitlsl-du
Genetic Background: C3H/HeJ-Kitlsl-du

Allelic Composition: KitlSl-10H/KitlSl-10H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-so/KitlSl-so
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-21H/KitlSl-21H
Genetic Background: involves: C3H/HeH

Allelic Composition: Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic Background: BKa.129S6-Kitltm1.1Sjm

Allelic Composition: Kitltm2.2Sjm/Kitltm2.2Sjm
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm2.1Sjm/Kitltm2.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: KitlSl-34H/KitlSl-34H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: KitlSl-2Neu/KitlSl-2Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-3Neu/KitlSl-3Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-3R/KitlSl-12R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-12R/KitlSl-12R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-2Neu/KitlSl-2Neu
Genetic Background: involves: 102/El * C3H/El

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-12R/Kitl+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitlSl-d/Kitl+
Genetic Background: either: DBA/2J or (C57BL/6 x DBA/2)F1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-v/Kit+,Tg(Mt1-RET)304Ina/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl/Kitl+,Tg(PGK1-KITLG*220)441Daw/0
Genetic Background: involves: C3H

Allelic Composition: KitlSl-d/Kitl+,Ph/Ph+
Genetic Background: involves: C57BL/Gr * DBA/2J

Allelic Composition: KitlM1Bao/KitlM1Bao
Genetic Background: involves: C57BL/6J

Allelic Composition: KitlSl-so/Kitl+
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-so/KitlSl-so
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-m/Kitl+
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-Clo/Kitl+
Genetic Background: Not Specified

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

Allelic Composition: KitlSl/KitlSl-Clo
Genetic Background: Not Specified

Allelic Composition: KitlSl-13H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-15H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-21H/Kitl+
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-26H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-27H/Kitl+
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-31H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-33H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-29H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-28R/Kitl+
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-13H/KitlSl-13H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-15H/KitlSl-15H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-d/Kitl+
Genetic Background: either: DBA/2J or (C57BL/6 x DBA/2)F1

Allelic Composition: KitlSl-3R/KitlSl-12R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-12R/KitlSl-12R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CrygdAey4/Crygd+
Genetic Background: C3HeB/FeJ-CrygdAey4

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/Kitl+
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/Kitl+
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/Kitl+
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/Kitl+
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/Kitl+
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-39R/Kitl+
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: KitlSl-18R/KitlSl-18R
Genetic Background: C3.Cg-KitlSl-18R

Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/KitlSl-31R
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-36R/Kitl+
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/KitlSl-28R
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/KitlSl-30R
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/KitlSl-42R
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-39R/Kitl+
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-J/KitlSl-J
Genetic Background: C3HeB/FeHu-KitlSl-J

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-22R/Kitl+
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/Kitl+
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-31R/KitlSl-31R
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-36R/Kitl+
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/KitlSl-28R
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-28R/Kitl+
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/KitlSl-30R
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-30R/Kitl+
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/Kitl+
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-42R/KitlSl-42R
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-39R/Kitl+
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: involves: DBA/2J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/KitlSl-2Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-5R/Kitl+
Genetic Background: C3.Cg-KitlSl-5R

Allelic Composition: KitlSl-18R/Kitl+
Genetic Background: C3.Cg-KitlSl-18R

Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Allelic Composition: Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic Background: BKa.129S6-Kitltm1.1Sjm

Allelic Composition: Kitltm2.1Sjm/Kitltm2.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-17H/Kitl+
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-17H/KitlSl-con
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-3Neu/KitlSl-3Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-J/Kitl+
Genetic Background: C3HeB/FeHu-KitlSl-J

Allelic Composition: KitlSl-10H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlM1Bao/Kitl+
Genetic Background: involves: C57BL/6J

Allelic Composition: KitlSl-16J/Kitl+
Genetic Background: involves: 129 * Lipari

Allelic Composition: KitlSl-34H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002939 head spot "the appearance of a round area of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-17H/Kitl+
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-22R/Kitl+
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/Kitl+
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/Kitl+
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/Kitl+
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/Kitl+
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/Kitl+
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/Kitl+
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-2Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-d/Kitl+,Ph/Ph+
Genetic Background: involves: C57BL/Gr * DBA/2J

Allelic Composition: KitlSl-10H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-t/KitlSl-t
Genetic Background: WB.Cg-KitlSl-t

Allelic Composition: KitlSl-13H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-15H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-21H/Kitl+
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-26H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-29H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002940 variable body spotting "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kitlsl-du/Kitlsl-du
Genetic Background: C3H/HeJ-Kitlsl-du

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

Allelic Composition: Kitlsl-24J/Kitlsl-24J
Genetic Background: B6;129S1-a Kitlsl-24J/GrsrJ

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

 MP:0003282 gastric ulcer "a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0004478 testicular teratoma "neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: KitlSl-J/Kitl+
Genetic Background: involves: 129

 MP:0004806 absent germ cells "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: KitlSl-J/KitlSl-J
Genetic Background: C3HeB/FeHu-KitlSl-J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-18H/Kitl+,X/SryAKR/J
Genetic Background: involves: AKR/J * C57BL/6J

Allelic Composition: Kitltm2.1Pbes/Kitltm2.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-22J/Kitl+
Genetic Background: C57BL/6J-KitlSl-22J/GrsrJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kitltm2.1Pbes/KitlSl
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6J * FVB/N

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0005171 lack of coat pigmentation "fur is devoid of coloration and appears white " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-3R/KitlSl-12R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-12R/KitlSl-12R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Allelic Composition: KitlSl-d/Kitl+,rs/rs
Genetic Background: involves: C3H/HeJ * DBA/2J

Allelic Composition: KitlSl-t/KitlSl-t
Genetic Background: WB.Cg-KitlSl-t

Allelic Composition: KitlSl-t/KitlSl-t
Genetic Background: B6.Cg-KitlSl-t

Allelic Composition: KitlSl-so/KitlSl-so
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-m/KitlSl-m
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl/KitlSl-Clo
Genetic Background: Not Specified

Allelic Composition: KitlSl/KitlSl-17J
Genetic Background: involves: BALB/cGr * C3HeB/FeJ

Allelic Composition: KitlSl-d/KitlSl-18J
Genetic Background: involves: C3H/HeJ * C57BL/6J * DBA/2J

Allelic Composition: KitlSl-19J/KitlSl-19J
Genetic Background: C3HeB/FeJ

Allelic Composition: KitlSl-29H/KitlSl-29H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005175 non-pigmented tail tip "lack of color at the end of the tail " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: KitlSl-t/Kitl+
Genetic Background: B6.Cg-KitlSl-t

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl/Kitl+,Tg(PGK1-KITLG*220)441Daw/0
Genetic Background: involves: C3H

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-con/Kitl+
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-22R/Kitl+
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/Kitl+
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-36R/Kitl+
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/Kitl+
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/Kitl+
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/Kitl+
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-39R/Kitl+
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-1Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Faslpr/Fastm1.1Cgn
Genetic Background: involves: C57BL/6 * MRL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0006205 embryonic lethality before somite formation "death anytime after implantation but before somite formation (E4.5 to less than E8)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kitltm2.1Pbes/Kitltm2.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0008237 abnormal ventral coat pigmentation "irregular or unusual pigmentation of ventrum hair in relation to control animals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-22R/Kitl+
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/Kitl+
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/Kitl+
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/Kitl+
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/Kitl+
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/Kitl+
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/Kitl+
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/Kitl+
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Baxtm1Sjk/Bax+,KitlSl/KitlSl,Tg(Pou5f1-GFP)1Scho/?
Genetic Background: involves: 129X1/SvJ * C3H * CD-1 * FVB

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: involves: C3H

Allelic Composition: KitlSl-pan/Kitl+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-pan/KitlSl-pan
Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-17H/Kitl+
Genetic Background: C3H/HeH-KitlSl-17H

Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/KitlSl-31R
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-28R/KitlSl-28R
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-30R/KitlSl-30R
Genetic Background: C3.101Rl-KitlSl-30R

Allelic Composition: KitlSl-42R/KitlSl-42R
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

Allelic Composition: KitlSl-d/KitlSl-d
Genetic Background: C3.D2-KitlSl-d

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-5R/KitlSl-5R
Genetic Background: C3H-KitlSl-5R

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

 MP:0008857 myelencephalic blebs "presence of blister-like structures formed on the posterior portion of the embryonic hindbrain that are usually filled with blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Allelic Composition: Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic Background: BKa.129S6-Kitltm1.1Sjm

Allelic Composition: Kitltm2.1Sjm/Kitltm2.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm2.1Sjm/Kitltm2.2Sjm,Tg(Tek-cre)12Flv/0
Genetic Background: involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0009379 abnormal foot pigmentation "anomaly in the coloration of the foot" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: KitlSl-22J/Kitl+
Genetic Background: C57BL/6J-KitlSl-22J/GrsrJ

Allelic Composition: KitlSl-10H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlM1Bao/Kitl+
Genetic Background: involves: C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009933 abnormal tail hair pigmentation "an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlM1Bao/Kitl+
Genetic Background: involves: C57BL/6J

Allelic Composition: KitlSl-so/Kitl+
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-13H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-15H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-21H/Kitl+
Genetic Background: involves: C3H/HeH

Allelic Composition: KitlSl-30H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-33H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009934 abnormal hind foot hair pigmentation "an anomaly in the expected color gradient of hair covering the metatarsals and phalanges often differentially expressed in females and males" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-29H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0010275 increased melanoma incidence "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: KitW-v/Kit+,Tg(Mt1-RET)304Ina/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0010784 abnormal forestomach morphology "any structural anomaly of the dilated area of tissue where the stomach and esophagus meet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl/KitlSl-d
Genetic Background: involves: C57BL/6 * WC

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: KitlSl-18R/KitlSl-18R
Genetic Background: C3.Cg-KitlSl-18R

Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/KitlSl-31R
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-28R/KitlSl-28R
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-42R/KitlSl-42R
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-so/KitlSl-so
Genetic Background: involves: C57BL/6

Allelic Composition: KitlSl-21H/KitlSl-21H
Genetic Background: involves: C3H/HeH

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: KitlSl-18H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-36R/KitlSl-36R
Genetic Background: C3H-KitlSl-36R

Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-J/KitlSl-J
Genetic Background: C3HeB/FeHu-KitlSl-J

Allelic Composition: KitlSl-31H/KitlSl-31H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic Background: BKa.129S6-Kitltm1.1Sjm

Allelic Composition: Kitltm2.2Sjm/Kitltm2.2Sjm
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: KitlSl-18R/KitlSl-18R
Genetic Background: C3.Cg-KitlSl-18R

Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/KitlSl-31R
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-28R/KitlSl-28R
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-42R/KitlSl-42R
Genetic Background: C3.101Rl-KitlSl-42R

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: KitlSl-3R/Kitl+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: KitlSl-27H/KitlSl-27H
Genetic Background: involves: C3H/HeH

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: KitlSl-30H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: KitlSl-34H/KitlSl-34H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: KitlSl/KitlSl
Genetic Background: involves: C3H

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

Allelic Composition: KitlSl-10H/KitlSl-10H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: KitlSl-22R/KitlSl-22R
Genetic Background: C3H-KitlSl-22R

Allelic Composition: KitlSl-31R/KitlSl-31R
Genetic Background: C3H-KitlSl-31R

Allelic Composition: KitlSl-28R/KitlSl-28R
Genetic Background: C3.101Rl-KitlSl-28R

Allelic Composition: KitlSl-42R/KitlSl-42R
Genetic Background: C3.101Rl-KitlSl-42R

Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: KitlSl-31H/KitlSl-31H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: KitlSl-gb/KitlSl-gb
Genetic Background: C3.Cg-KitlSl-gb

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Kitltm1.1Sjm/Kitltm1.1Sjm
Genetic Background: BKa.129S6-Kitltm1.1Sjm

Allelic Composition: Kitltm2.2Sjm/Kitl+
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm2.1Sjm/Kitltm2.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm2.1Sjm/Kitltm2.2Sjm,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: BALB/cJ * C57BL * CBA/Ca * SJL

Allelic Composition: Kitltm2.1Sjm/Kitltm2.2Sjm,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/Ka * CD-1 * SJL

Allelic Composition: Kitltm2.1Sjm/Kitltm2.2Sjm,Tg(Tek-cre)12Flv/0
Genetic Background: involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0011188 increased erythrocyte protoporphyrin level "an accumulation of the intermediates of heme biosynthesis in red blood cells" [MGI:csmith]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: KitlSl-22J/Kitl+
Genetic Background: C57BL/6J-KitlSl-22J/GrsrJ

Allelic Composition: Kitlsl-24J/Kitlsl-24J
Genetic Background: B6;129S1-a Kitlsl-24J/GrsrJ

 MP:0011278 increased ear pigmentation "visually detectable excess of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: KitlSl-1Neu/KitlSl-1Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: KitlSl-3Neu/KitlSl-3Neu
Genetic Background: involves: 102/El * C3H/El

 MP:0011279 decreased ear pigmentation "visually detectable dilution of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: KitlSl-22J/Kitl+
Genetic Background: C57BL/6J-KitlSl-22J/GrsrJ

 MP:0011568 decreased foot pigmentation "visually detectable dilution of pigment present on the foot surface" [MGI:csmith]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: Kitlsl-24J/Kitlsl-24J
Genetic Background: B6;129S1-a Kitlsl-24J/GrsrJ

 MP:0011610 abnormal primordial germ cell apoptosis "change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb]
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Allelic Composition: KitlSl-39R/KitlSl-39R
Genetic Background: C3.B10Rl-KitlSl-39R

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000004837 Grap / Q9CX99 / GRB2-related adapter protein / GRAPL* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2 related adaptor protein like*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex
 ENSMUSG00000017737 Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*  / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000042594 Sh2b3 / O09039 / SH2B adapter protein 3 / Q9UQQ2* / SH2B adaptor protein 3*  / complex / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex / reaction
 ENSMUSG00000000127 Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / reaction / complex
 ENSMUSG00000022225 Cma1 / P21844 / Chymase / P23946* / chymase 1*  / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction
 ENSMUSG00000056153 Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / reaction / complex






 

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