ENSMUSG00000020919


Mus musculus

Features
Gene ID: ENSMUSG00000020919
  
Biological name :Stat5b
  
Synonyms : P42232 / Signal transducer and activator of transcription 5B / Stat5b
  
Possible biological names infered from orthology : P51692
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100780731
Gene end: 100850724
  
Corresponding Affymetrix probe sets: 10391286 (MoGene1.0st)   1422102_a_at (Mouse Genome 430 2.0 Array)   1422103_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004143
Ensembl peptide - ENSMUSP00000102981
NCBI entrez gene - 20851     See in Manteia.
MGI - MGI:103035
RefSeq - XM_017314403
RefSeq - NM_001113563
RefSeq - NM_011489
RefSeq - XM_006532723
RefSeq Peptide - NP_001107035
RefSeq Peptide - NP_035619
swissprot - P42232
Ensembl - ENSMUSG00000020919
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat5aENSDARG00000019392Danio rerio
 stat5bENSDARG00000055588Danio rerio
 STAT5BENSGALG00000003282Gallus gallus
 P51692ENSG00000173757Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*ENSMUSG0000000404385
Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*ENSMUSG0000000214738
Stat4 / signal transducer and activator of transcription 4 / Q14765*ENSMUSG0000006293928
Stat1 / signal transducer and activator of transcription 1 / P42224*ENSMUSG0000002610428
Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*ENSMUSG0000000404028
Stat2 / signal transducer and activator of transcription 2 / P52630*ENSMUSG0000004003324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR035858  STAT5a/5b
 IPR035886  STAT5b, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000255 allantoin metabolic process IMP
 biological_processGO:0001553 luteinization IGI
 biological_processGO:0001779 natural killer cell differentiation IGI
 biological_processGO:0006101 citrate metabolic process IMP
 biological_processGO:0006103 2-oxoglutarate metabolic process IMP
 biological_processGO:0006105 succinate metabolic process IMP
 biological_processGO:0006107 oxaloacetate metabolic process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006549 isoleucine metabolic process IMP
 biological_processGO:0006573 valine metabolic process IMP
 biological_processGO:0006600 creatine metabolic process IMP
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade IDA
 biological_processGO:0007548 sex differentiation IMP
 biological_processGO:0007565 female pregnancy IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0019218 regulation of steroid metabolic process IGI
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019530 taurine metabolic process IMP
 biological_processGO:0019915 lipid storage IGI
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030856 regulation of epithelial cell differentiation IMP
 biological_processGO:0032355 response to estradiol ISO
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IMP
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IMP
 biological_processGO:0032870 cellular response to hormone stimulus ISO
 biological_processGO:0033077 T cell differentiation in thymus IGI
 biological_processGO:0040014 regulation of multicellular organism growth IDA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0042448 progesterone metabolic process IGI
 biological_processGO:0043029 T cell homeostasis IGI
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IGI
 biological_processGO:0045579 positive regulation of B cell differentiation IGI
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation IGI
 biological_processGO:0045621 positive regulation of lymphocyte differentiation IGI
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IGI
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISS
 biological_processGO:0045931 positive regulation of mitotic cell cycle IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0046449 creatinine metabolic process IMP
 biological_processGO:0046543 development of secondary female sexual characteristics IMP
 biological_processGO:0046544 development of secondary male sexual characteristics IMP
 biological_processGO:0048541 Peyer"s patch development IGI
 biological_processGO:0050729 positive regulation of inflammatory response IGI
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IDA
 biological_processGO:0070669 response to interleukin-2 IMP
 biological_processGO:0070670 response to interleukin-4 IMP
 biological_processGO:0070672 response to interleukin-15 IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0097531 mast cell migration IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035259 glucocorticoid receptor binding ISO
 molecular_functionGO:0046983 protein dimerization activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Signaling by SCF-KIT
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

 MP:0001881 abnormal mammary gland physiology "aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(Mnx1-Zfp106,-EGFP)2Blk/0,Zfp106tm1b(KOMP)Wtsi/Zfp106tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0003838 abnormal milk ejection "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926]
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0010172 abnormal mammary gland epithelium physiology "any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011532 decreased urine major urinary protein level "reduced amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine" [MGI:csmith]
Show

Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0011696 absent mast cells "any structural anomaly of a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation; progenitors leave bone marrow and mature in connective and mucosal tissue; mature mast cells are found in all tissues, except the bloodstream." [CL:0000097]
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / complex / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex / reaction
 ENSMUSG00000020279 Il9r / Q01114 / Interleukin-9 receptor / Q01113*  / complex / reaction
 ENSMUSG00000021538 Il9 / P15247 / Interleukin-9 / P15248*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / reaction / complex
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / reaction / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / reaction / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex / reaction
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / complex






 

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