Manteia

ENSG00000173757

Homo sapiens

Features

Gene ID:	ENSG00000173757

Biological name :	STAT5B

Synonyms :	P51692 / signal transducer and activator of transcription 5B / STAT5B

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	-1
Band:	q21.2
Gene start:	42199168
Gene end:	42276707

Corresponding Affymetrix probe sets:	1555086_at (Human Genome U133 Plus 2.0 Array) 1555088_x_at (Human Genome U133 Plus 2.0 Array) 205026_at (Human Genome U133 Plus 2.0 Array) 212549_at (Human Genome U133 Plus 2.0 Array) 212550_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000293328 Ensembl peptide - ENSP00000398379 NCBI entrez gene - 6777 See in Manteia. OMIM - 604260 RefSeq - NM_012448 RefSeq - XM_017024977 RefSeq Peptide - NP_036580 swissprot - C9J4I3 swissprot - P51692 Ensembl - ENSG00000173757

Related genetic diseases (OMIM):	102578 - Leukemia, acute promyelocytic, somatic, 102578
	245590 - Growth hormone insensitivity with immunodeficiency, 245590

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
stat5a	ENSDARG00000019392	Danio rerio
stat5b	ENSDARG00000055588	Danio rerio
STAT5B	ENSGALG00000003282	Gallus gallus
P42232	ENSMUSG00000020919	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P42229 / STAT5A / signal transducer and activator of transcription 5A	ENSG00000126561	93
STAT6 / P42226 / signal transducer and activator of transcription 6	ENSG00000166888	37
STAT4 / Q14765 / signal transducer and activator of transcription 4	ENSG00000138378	28
STAT1 / P42224 / signal transducer and activator of transcription 1	ENSG00000115415	28
STAT3 / P40763 / signal transducer and activator of transcription 3	ENSG00000168610	28
STAT2 / P52630 / signal transducer and activator of transcription 2	ENSG00000170581	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR001217	Transcription factor STAT
IPR008967	p53-like transcription factor, DNA-binding
IPR012345	STAT transcription factor, DNA-binding, N-terminal
IPR013799	STAT transcription factor, protein interaction
IPR013800	STAT transcription factor, all-alpha domain
IPR013801	STAT transcription factor, DNA-binding
IPR015988	STAT transcription factor, coiled coil
IPR035858	STAT5a/5b
IPR035886	STAT5b, SH2 domain
IPR036535	STAT transcription factor, N-terminal domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000255	allantoin metabolic process	IEA
biological_process	GO:0001553	luteinization	IEA
biological_process	GO:0001779	natural killer cell differentiation	IEA
biological_process	GO:0006101	citrate metabolic process	IEA
biological_process	GO:0006103	2-oxoglutarate metabolic process	IEA
biological_process	GO:0006105	succinate metabolic process	IEA
biological_process	GO:0006107	oxaloacetate metabolic process	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006549	isoleucine metabolic process	IEA
biological_process	GO:0006573	valine metabolic process	IEA
biological_process	GO:0006600	creatine metabolic process	IEA
biological_process	GO:0006631	fatty acid metabolic process	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007259	JAK-STAT cascade	IEA
biological_process	GO:0007548	sex differentiation	IEA
biological_process	GO:0007565	female pregnancy	IEA
biological_process	GO:0007595	lactation	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0019218	regulation of steroid metabolic process	IEA
biological_process	GO:0019221	cytokine-mediated signaling pathway	IEA
biological_process	GO:0019530	taurine metabolic process	IEA
biological_process	GO:0019915	lipid storage	IEA
biological_process	GO:0030155	regulation of cell adhesion	IEA
biological_process	GO:0030856	regulation of epithelial cell differentiation	IEA
biological_process	GO:0032355	response to estradiol	IDA
biological_process	GO:0032819	positive regulation of natural killer cell proliferation	IEA
biological_process	GO:0032825	positive regulation of natural killer cell differentiation	IEA
biological_process	GO:0032870	cellular response to hormone stimulus	IDA
biological_process	GO:0033077	T cell differentiation in thymus	IEA
biological_process	GO:0035723	interleukin-15-mediated signaling pathway	TAS
biological_process	GO:0038110	interleukin-2-mediated signaling pathway	TAS
biological_process	GO:0038111	interleukin-7-mediated signaling pathway	TAS
biological_process	GO:0040014	regulation of multicellular organism growth	IEA
biological_process	GO:0040018	positive regulation of multicellular organism growth	IEA
biological_process	GO:0042104	positive regulation of activated T cell proliferation	IEA
biological_process	GO:0042448	progesterone metabolic process	IEA
biological_process	GO:0043029	T cell homeostasis	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IEA
biological_process	GO:0045086	positive regulation of interleukin-2 biosynthetic process	IEA
biological_process	GO:0045579	positive regulation of B cell differentiation	IEA
biological_process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IEA
biological_process	GO:0045621	positive regulation of lymphocyte differentiation	IEA
biological_process	GO:0045647	negative regulation of erythrocyte differentiation	IEA
biological_process	GO:0045648	positive regulation of erythrocyte differentiation	IDA
biological_process	GO:0045931	positive regulation of mitotic cell cycle	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IEA
biological_process	GO:0046449	creatinine metabolic process	IEA
biological_process	GO:0046543	development of secondary female sexual characteristics	IEA
biological_process	GO:0046544	development of secondary male sexual characteristics	IEA
biological_process	GO:0048541	Peyer"s patch development	IEA
biological_process	GO:0050729	positive regulation of inflammatory response	IEA
biological_process	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	IEA
biological_process	GO:0070669	response to interleukin-2	IEA
biological_process	GO:0070670	response to interleukin-4	IEA
biological_process	GO:0070672	response to interleukin-15	IEA
biological_process	GO:0071363	cellular response to growth factor stimulus	IEA
biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	ISS
biological_process	GO:0097531	mast cell migration	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	TAS
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	NAS
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	ISS
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	TAS
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0035259	glucocorticoid receptor binding	IPI
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

Prolactin receptor signaling

Interleukin-7 signaling

Signaling by SCF-KIT

Signaling by cytosolic FGFR1 fusion mutants

Downstream signal transduction

Signaling by Leptin

Interleukin-3, Interleukin-5 and GM-CSF signaling

Interleukin-20 family signaling

Interleukin-15 signaling

Interleukin-9 signaling

Interleukin-2 signaling

Interleukin-21 signaling

Growth hormone receptor signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
HP:0000824	Growth hormone deficiency	"Insufficient production of growth hormone, which is produced by the anterior pituitary gland." [HPO:curators]	Show
HP:0002098	Respiratory distress		Show
HP:0003510	Short stature, severe	"A severe degree of short stature." [HPO:curators]	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000187266	EPOR / P19235 / erythropoietin receptor	/ reaction / complex
ENSG00000049130	KITLG / P21583 / KIT ligand	/ reaction / complex
ENSG00000111790	Q9NVK5 / FGFR1OP2 / FGFR1 oncogene partner 2	/ reaction
ENSG00000130427	EPO / P01588 / erythropoietin	/ reaction / complex
ENSG00000113525	IL5 / P05113 / interleukin 5	/ reaction / complex
ENSG00000112964	GHR / P10912 / growth hormone receptor	/ complex / reaction
ENSG00000113494	PRLR / P16471 / prolactin receptor	/ reaction / complex
ENSG00000091181	IL5RA / Q01344 / interleukin 5 receptor subunit alpha	/ reaction / complex
ENSG00000100368	CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit	/ reaction / complex
ENSG00000168610	STAT3 / P40763 / signal transducer and activator of transcription 3	/ complex / reaction
ENSG00000174697	LEP / leptin / P41159	/ reaction / complex
ENSG00000164399	IL3 / P08700 / interleukin 3	/ reaction / complex
ENSG00000164400	CSF2 / P04141 / colony stimulating factor 2	/ reaction / complex
ENSG00000105639	JAK3 / P52333 / Janus kinase 3	/ reaction / complex
ENSG00000157404	KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase	/ complex / reaction
ENSG00000124334	IL9R / Q01113 / interleukin 9 receptor	/ reaction / complex
ENSG00000145839	IL9 / P15248 / interleukin 9	/ complex / reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000168685	IL7R / P16871 / interleukin 7 receptor	/ complex
ENSG00000185291	IL3RA / P26951 / interleukin 3 receptor subunit alpha	/ complex / reaction
ENSG00000173757	P51692 / STAT5B / signal transducer and activator of transcription 5B	/ reaction / complex
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ reaction / complex
ENSG00000104432	IL7 / P13232 / interleukin 7	/ complex
ENSG00000147168	IL2RG / P31785 / interleukin 2 receptor subunit gamma	/ reaction / complex
ENSG00000257923	CUX1 / P39880 / Q13948 / cut like homeobox 1	/ reaction
ENSG00000186716	BCR / P11274 / BCR, RhoGEF and GTPase activating protein	/ reaction
ENSG00000172179	PRL / P01236 / prolactin	/ reaction / complex
ENSG00000259384	GH1 / P01241 / growth hormone 1	/ complex / reaction
ENSG00000136487	GH2 / P01242 / growth hormone 2	/ reaction / complex
ENSG00000136488	CSH1 / P0DML2 / chorionic somatomammotropin hormone 1	/ reaction / complex
ENSG00000198223	CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit	/ complex / reaction
ENSG00000116678	LEPR / P48357 / leptin receptor	/ complex / reaction
ENSG00000115415	STAT1 / P42224 / signal transducer and activator of transcription 1	/ complex / reaction
ENSG00000126561	P42229 / STAT5A / signal transducer and activator of transcription 5A	/ reaction / complex
ENSG00000121741	ZMYM2 / Q9UBW7 / zinc finger MYM-type containing 2	/ reaction
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ complex / reaction
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr