ENSG00000166888


Homo sapiens

Features
Gene ID: ENSG00000166888
  
Biological name :STAT6
  
Synonyms : P42226 / signal transducer and activator of transcription 6 / STAT6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 57095408
Gene end: 57132139
  
Corresponding Affymetrix probe sets: 201331_s_at (Human Genome U133 Plus 2.0 Array)   201332_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452394
Ensembl peptide - ENSP00000452373
Ensembl peptide - ENSP00000491116
Ensembl peptide - ENSP00000300134
Ensembl peptide - ENSP00000401486
Ensembl peptide - ENSP00000438451
Ensembl peptide - ENSP00000444530
Ensembl peptide - ENSP00000445409
Ensembl peptide - ENSP00000450428
Ensembl peptide - ENSP00000450510
Ensembl peptide - ENSP00000450665
Ensembl peptide - ENSP00000450732
Ensembl peptide - ENSP00000450747
Ensembl peptide - ENSP00000450921
Ensembl peptide - ENSP00000451074
Ensembl peptide - ENSP00000451209
Ensembl peptide - ENSP00000451546
Ensembl peptide - ENSP00000451742
Ensembl peptide - ENSP00000451909
Ensembl peptide - ENSP00000452203
NCBI entrez gene - 6778     See in Manteia.
OMIM - 601512
RefSeq - XM_011538709
RefSeq - NM_001178078
RefSeq - NM_001178079
RefSeq - NM_001178080
RefSeq - NM_001178081
RefSeq - NM_003153
RefSeq - XM_006719575
RefSeq - XM_011538703
RefSeq - XM_011538704
RefSeq - XM_011538705
RefSeq - XM_011538706
RefSeq - XM_011538707
RefSeq - XM_011538708
RefSeq Peptide - NP_003144
RefSeq Peptide - NP_001171549
RefSeq Peptide - NP_001171550
RefSeq Peptide - NP_001171551
RefSeq Peptide - NP_001171552
swissprot - H0YIY2
swissprot - H0YJH6
swissprot - G3V2H4
swissprot - G3V2L2
swissprot - G3V2M3
swissprot - G3V2X7
swissprot - G3V370
swissprot - G3V3E9
swissprot - G3V568
swissprot - G3V5I8
swissprot - P42226
swissprot - Q5FBW6
swissprot - A0A1W2PNW1
swissprot - G3V5K5
Ensembl - ENSG00000166888
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat6ENSDARG00000015902Danio rerio
 Stat6ENSMUSG00000002147Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P42229 / STAT5A / signal transducer and activator of transcription 5AENSG0000012656135
P51692 / STAT5B / signal transducer and activator of transcription 5BENSG0000017375735
STAT1 / P42224 / signal transducer and activator of transcription 1ENSG0000011541522
STAT4 / Q14765 / signal transducer and activator of transcription 4ENSG0000013837821
STAT2 / P52630 / signal transducer and activator of transcription 2ENSG0000017058121
STAT3 / P40763 / signal transducer and activator of transcription 3ENSG0000016861020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR028187  STAT6, C-terminal
 IPR035857  STAT6, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002296 T-helper 1 cell lineage commitment IEA
 biological_processGO:0002829 negative regulation of type 2 immune response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035771 interleukin-4-mediated signaling pathway IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048295 positive regulation of isotype switching to IgE isotypes IEA
 biological_processGO:0060443 mammary gland morphogenesis IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:1902170 cellular response to reactive nitrogen species IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
STAT6-mediated induction of chemokines
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / complex / reaction
 ENSG00000113520 IL4 / P05112 / interleukin 4  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / reaction / complex
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / complex / reaction
 ENSG00000169194 IL13 / P35225 / interleukin 13  / complex / reaction
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000184584 Q86WV6 / TMEM173 / transmembrane protein 173  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr