ENSG00000169194


Homo sapiens

Features
Gene ID: ENSG00000169194
  
Biological name :IL13
  
Synonyms : IL13 / interleukin 13 / P35225
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.1
Gene start: 132656263
Gene end: 132661110
  
Corresponding Affymetrix probe sets: 207844_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479835
Ensembl peptide - ENSP00000304915
NCBI entrez gene - 3596     See in Manteia.
OMIM - 147683
RefSeq - NM_001354991
RefSeq - NM_002188
RefSeq Peptide - NP_001341920
RefSeq Peptide - NP_002179
swissprot - P35225
swissprot - A0A087WW07
Ensembl - ENSG00000169194
  
Related genetic diseases (OMIM): 600807 - {Asthma, susceptibility to}, 600807
  607154 - {Allergic rhinitis, susceptibility to}, 607154
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il13ENSMUSG00000020383Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001325  Interleukin-4/interleukin-13
 IPR009079  Four-helical cytokine-like, core
 IPR018096  Interleukin-4/interleukin-13, conserved site
 IPR020470  Interleukin-13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0002639 positive regulation of immunoglobulin production IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010155 regulation of proton transport IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032723 positive regulation of connective tissue growth factor production IEA
 biological_processGO:0033861 negative regulation of NAD(P)H oxidase activity IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043270 positive regulation of ion transport IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071635 negative regulation of transforming growth factor beta production IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901247 negative regulation of lung ciliated cell differentiation NAS
 biological_processGO:1901251 positive regulation of lung goblet cell differentiation NAS
 biological_processGO:1903660 negative regulation of complement-dependent cytotoxicity IMP
 biological_processGO:2000231 positive regulation of pancreatic stellate cell proliferation IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005144 interleukin-13 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / reaction / complex
 ENSG00000123496 Q14627 / IL13RA2 / interleukin 13 receptor subunit alpha 2  / reaction / complex
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction






 

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